青钱柳冲剂对糖尿病小鼠的降血糖功效  

Antidiabetic Effect of Traditional Chinese Medicinal Cyclocarya paliurus Granules in Diabetic Mice

作　　者：李婷婷[1] 吴彩娥[1] 方升佐[1] 范龚建[1] 吴海霞[1] 

机构地区：[1]南京林业大学森林资源与环境学院,江苏南京210037

出　　处：《食品科学》2012年第15期287-290,共4页Food Science

基　　金：江苏高校优势学科建设工程资助项目(PAPD);国家林业局林业公益性行业科研专项项目(200904046);江苏高等学校创新团队科研计划(苏教科[2009]10号);南京林业大学森林资源与环境学院青年基金项目[2009]

摘　　要：研究青钱柳冲剂对链佐霉素所致糖尿病小鼠的降血糖功效。以链佐霉素诱导小鼠糖尿病模型,设置模型对照组、正常对照组、阳性对照组以及青钱柳冲剂低、中、高剂量组,给药21d后,测定小鼠的空腹血糖、体质量、总胆固醇、甘油三酯、肝糖原等指标,并对小鼠胰腺组织的病理切片进行显微镜观察病变情况。结果表明:与模型对照组相比,青钱柳冲剂各组均能显著降低链佐霉素致糖尿病小鼠空腹血糖水平和总胆固醇量,显著增加体质量和肝糖原含量,并能减轻胰岛细胞病变程度。提示青钱柳冲剂对糖尿病模型小鼠具有明显治疗作用,其作用机理与其能调节肝脏糖代谢、恢复病变胰岛细胞的结构和功能有关。The antidiabetic effect of Cyclocarya paliurus granules,a traditional Chinese medicine preparation based on Cyclocarya paliurus leaves,in streptozotocin（STZ） induced diabetic mice was evaluated in this study.Diabetes was induced in mice by using STZ.Model control,normal control,positive control and low,medium and high-dose Cyclocarya paliurus granule treatment groups were established.After 12 d of administration,the levels of fasting blood sugar,total cholesterol,triglyceride and hepatic glycogen and body weight in mice were measured.At the same time,histopathological examination of mouse pancreas was carried out to find pathological changes.The results showed that Cyclocarya paliurus granules significantly reduced blood glucose and total cholesterol levels in diabetic mice.In addition,Cyclocarya paliurus granules improved body weight and hepatic glycogen levels.Histopathological examination showed that Cyclocarya paliurus granules promoted the recovery of langerhans islet cells from pancreas necrosis associated with diabetes.All these data suggest that Cyclocarya paliurus granules have therapeutic effects on diabetic mice.The mechanism is probably related to their regulation of hepatic glucose metabolism and the function of langerhans islet cells.

关 键 词：青钱柳 冲剂 降血糖 糖尿病小鼠 

分 类 号：R965[医药卫生—药理学]