不同浓度绿茶及茶叶渣对黄曲霉霉素B_1致大鼠肝癌作用的影响  

EFFECT OF GREEN TEA AND INFUSED TEA RESIDUE ON AFLATOXIN B_2-INDUCED HEPATOCARCINOGENESIS IN RATS

作　　者：覃国忠[1] 严瑞琪[2] 李瑗[1] 覃柳亮[1] 段小娴[1] 

机构地区：[1]广西肿瘤防治研究所 [2]中山医科大学肿瘤中心

出　　处：《肿瘤》1990年第3期121-123,共3页Tumor

摘　　要：在研究癌的化学预防中,寻找拮抗化学致癌物的物质,越来越受到重视。我们曾报道茶叶及不同品种的绿茶对黄曲霉毒素B_1(AFB_1)致肝癌作用有显著的抑制效果,但在这些研究中,绿茶用量均为5％,为找出绿茶的最低有效剂量,选择了3种不同浓度的绿茶作实验研究,并用茶叶渣作对比实验,现报告如下。The effect of green tea at three dosages (2,4 and 6%) and the infused tea residue(6%) on aflatoxin B_1 (AFB_1)-induced precancerous gamma glutamyltranspeptidase(GGT) positive hepatocellular foci (GGT foci) in rats was studied by using the shortterm in vivo experimental model. The results showed that green tea at anyone dosagehad remarkable inhibitory effect on AFB_1-induced hepatocarcinogenesis. The numberand size of the GGT foci in these groups were significantly lesser and smaller than thecontrols. But the effect of the infused tea residue was much weaker, suggesting theeffective ingredients are mainly water soluble. The results indicate that drinkinggreen tea daily can prevent cancer.

关 键 词：绿茶 茶叶渣 肝癌 黄曲霉毒素B1 

分 类 号：R735.702[医药卫生—肿瘤]