Current therapeutic strategies for inflammation following traumatic spinal cord injury  

作　　者：Priyanka L.Singh Nitin Agarwal James C.Barrese Robert F.Heary 

机构地区：[1]Department of Neurological Surgery,UMDNJ-New Jersey Medical School,Newark,NJ 07101-1709,USA [2]Reynolds Family Spine Laboratory,Newark,NJ 07101-1709,USA

出　　处：《Neural Regeneration Research》2012年第23期1812-1821,共10页中国神经再生研究（英文版）

摘　　要：Damage from spinal cord injury occurs in two phases-the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult.Apart from damage sustained as a result of direct trauma to the spinal cord,the post-traumatic inflammatory response contributes significantly to functional motor deficits exacerbated by the secondary injury.Attenuating the detrimental aspects of the inflammatory response is a promising strategy to potentially ameliorate the secondary injury,and promote significant functional recovery.This review details how the inflammatory component of secondary injury to the spinal cord can be treated currently and in the foreseeable future.Damage from spinal cord injury occurs in two phases-the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult.Apart from damage sustained as a result of direct trauma to the spinal cord,the post-traumatic inflammatory response contributes significantly to functional motor deficits exacerbated by the secondary injury.Attenuating the detrimental aspects of the inflammatory response is a promising strategy to potentially ameliorate the secondary injury,and promote significant functional recovery.This review details how the inflammatory component of secondary injury to the spinal cord can be treated currently and in the foreseeable future.

关 键 词：acute spinal cord injury INFLAMMATION treatment secondary injury NEUROPROTECTIVE HYPOTHERMIA ERYTHROPOIETIN estrogen ETANERCEPT ROLIPRAM 

分 类 号：R651.2[医药卫生—外科学]