鳕鱼皮胶原蛋白肽的抗酒精性胃溃疡作用  

Anti-alcoholic gastric ulcer effect of collagen peptide extracted from skin of Walleye pollock

作　　者：王志聪[1] 孙京沙[1] 倪鑫[1] 侯虎[1] 包郁明[1] 李八方[1] 

机构地区：[1]中国海洋大学,山东青岛266003

出　　处：《中国海洋药物》2012年第5期17-22,共6页Chinese Journal of Marine Drugs

基　　金：国家海洋公益性行业科研专项(201105029;201205027);中国博士后科学基金(2012M511549)资助

摘　　要：目的探究鳕鱼皮胶原蛋白及其酶解梯级多肽的抗酒精性胃溃疡作用。方法从鳕鱼皮中提取胶原蛋白并酶解成不同分子量段的胶原肽,采用酒精诱导大鼠急性胃溃疡模型,试验组灌胃给予不同剂量的胶原肽,检测胃溃疡指数、胃溃疡抑制率并对胃溃疡病灶部位进行组织学观察。结果与模型组相比,各受试物均能够降低大鼠胃腺的出血损伤。低分子量胶原肽与高分子量胶原肽都能显著降低胃溃疡指数,胃溃疡抑制率分别为46.98%和46.46%(P<0.05);高剂量的胶原蛋白与中分子量胶原肽能极显著降低胃溃疡指数,胃溃疡抑制率分别为57.16%和65.16%(P<0.01)。结论鱼皮胶原蛋白及其酶解梯级多肽能够明显降低大鼠胃溃疡出血和溃疡指数,具有良好的抗酒精性胃溃疡作用。Objective To investigate the anti-alcoholic gastric ulcer effect of collagen and its series enzymatic peptides from Walleye pollock.Methods The collagen was extracted from skin of Walleye pollock and then broken down by enzymes into collagen peptides.The experimental groups were given different doses of collagen peptides by gavage.The acute model of gastric ulcer induced by oral ethanol was used to detect the ulcer index,the inhibition rate of gastric ulcer and histological observation of their lesion sites.Results Compared with model group,the samples could reduce the bleeding injury in glandular stomach.Both low molecular weight collagen peptide and high molecular weight collagen peptide could significantly reduce the ulcer index,the respective inhibition rates were 46.98 % and 46.46%（P0.05）;the high doses of collagen and medium molecular weight collagen peptides could very significantly reduce the ulcer index,the respective inhibition rates were 57.16% and 65.16%（P0.01）.Conclusions Collagen and its series enzymatic peptides from Walleye pollock can significantly reduce the gastric ulcer bleeding and ulcer index,and could be developed to a good anti-gastric ulcer medicine.

关 键 词：鳕鱼 胶原蛋白肽 胃溃疡 溃疡指数 

分 类 号：R965[医药卫生—药理学]