食物过敏原标准物质的研究进展  

Research progress of food allergen reference material

作　　者：周煌[1,2] 杨安树[1,2] 佟平[1] 袁角建[1,2] 陈红兵[1,2] 高金燕[3] 

机构地区：[1]南昌大学食品科学与技术国家重点实验室,江西南昌330047 [2]南昌大学中德联合研究院,江西南昌330047 [3]南昌大学生命科学与食品工程学院,江西南昌330047

出　　处：《食品工业科技》2012年第23期438-442,共5页Science and Technology of Food Industry

基　　金：国家自然科学基金(31060215;21162019;31171716);国家科技支撑计划项目(2011BAK10B03;2012BAK17B02);南昌大学食品科学与技术国家重点实验室项目(SKLF-MB-201002;SKLF-TS-201109);江西省国际合作项目(2011BDH80026;2012BDH80019)

摘　　要：食物过敏原标准物质是解决食物过敏问题的关键实验材料之一。在食物过敏原标准化方面,鸡蛋、牛奶和花生过敏原的分离纯化、结构和免疫学性质表征方面取得了良好的效果,为研发单个过敏原蛋白标准物质提供了支撑。在美国国家标准与技术研究院(NIST)颁布的8种过敏性食物标准物质中,只有RM8445用于检测食物过敏原;由欧盟资助的两大项目中,EuroPrevall项目主要构建了一个食物过敏原信息的数据库,而CREATE项目则首次证实重组花粉过敏原rBetv1可作为天然花粉过敏原Betv1的候选标准物质,为开发重组食物过敏原标准物质提供了一种可借鉴的策略。总之,研发食物过敏原致敏性蛋白标准物质是一项重要的任务,极具挑战性。Food allergen reference material is an important material to deal with the problem of food allergy.In the aspects of food allergen standardization ,achievements have been made in purification ,structure and immunology characterization towards egg ,milk and peanut,which provide support for the research and development of single allergen.So far,National Institute of Standards and Technology（NIST） has produced eight allergic food reference materials.However,only RM 8445 was produced for the evaluation of the commercial kits used for the detecting of egg.In EU-funded project, EuroPrevall project has develop a food allergen library, and CREATE project first demonstrate that rBet v 1 can be the candidate of reference standard for Bet v 1 ,which provide a good strategy for the development of food allergen reference material. In a word, the study of food allergenic protein reference materials is an important and challenge work.

关 键 词：食物过敏 过敏原 标准物质 

分 类 号：TS207.2[轻工技术与工程—食品科学]