Effects of Conjugated Linoleic Acids on Proliferation and Differentiation of Rat Preadipocytes  

作　　者：LI Ying 

机构地区：[1]College of Life Science, Chongqing Normal University, Chongqing 400047, China

出　　处：《Animal Husbandry and Feed Science》2010年第2期17-19,共3页动物与饲料科学（英文版）

基　　金：funded by Scientific and Technological Research Project of Chongqing Municipal Education Commission (KJ080827);National Natural Science Foundation of China (30800843);the Key Disciplines of Zoology of chongqing, chongqing Normal University

摘　　要：Conjugated linoleic acids （CLAs） are a generic term for linoleic acid isomers and have a variety of biological functions. After rat preadi- pocytes were incubated in CLAs-supplemented media, their proliferation and differentiation were observed by the cell count and the oil red O stai- ning. The results showed that the CLAs at different concentrations inhibited proliferation of the rat preadipocytes in a time- and dose-dependent manner. And the CLAs greatly decreased intracellular lipid content in mature adipocytes. Moreover, lipogenesis was inhibited by the CLAs in a dose-dependent manner. Therefore, the CLAs inhibit the lipogenesis by reducing the number of preadipocytes and decreasing the intracellular lipidConjugated linoleic acids （CLAs） are a generic term for linoleic acid isomers and have a variety of biological functions. After rat preadi- pocytes were incubated in CLAs-supplemented media, their proliferation and differentiation were observed by the cell count and the oil red O stai- ning. The results showed that the CLAs at different concentrations inhibited proliferation of the rat preadipocytes in a time- and dose-dependent manner. And the CLAs greatly decreased intracellular lipid content in mature adipocytes. Moreover, lipogenesis was inhibited by the CLAs in a dose-dependent manner. Therefore, the CLAs inhibit the lipogenesis by reducing the number of preadipocytes and decreasing the intracellular lipid

关 键 词：Conjugated linoleic acids PREADIPOCYTES ADIPOCYTES PROLIFERATION DIFFERENTIATION 

分 类 号：S852.2[农业科学—基础兽医学] S816.7[农业科学—兽医学]