化学法除去6-碘代地奥司明的研究  

Study on the chemical method to remove 6-iododiosmin

作　　者：甘勇军[1] 彭俊[2] 方大树[2] 徐霞 胡湘南[2] 

机构地区：[1]重庆医科大学实验教学管理中心,重庆401331 [2]重庆医科大学药学院,重庆400016 [3]重庆礼邦药物开发有限公司,重庆401120

出　　处：《华西药学杂志》2012年第6期620-622,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究采用化学方法除去地奥司明反应产物中含有的6-碘代地奥司明。方法采用正交试验设计,以6-碘代地奥司明的含量、地奥司明的纯度和收率作为考察指标,对反应液中的氢氧化钠浓度、反应温度、反应时间进行选择。结果采用30%氢氧化钠作溶剂,在60℃反应1 h即能除去地奥司明反应产物中的6-碘代地奥司明,收率为92%。结论所用方法可较好地除去地奥司明反应产物中的6-碘代地奥司明,可用于地奥司明的纯化。OBJECTIVE To study the chemical method to remove 6-iododiosmin that was contained in diosmin reaction products.METHODS Orthogonal experimental design was employed.The concentration of NaOH,reaction temperature,reaction time,the content of 6-iododiosmin,purity and yield of diosmin were studied.RESULTS 6-Iododiosmin could be well removed from diosmin with the chemical reaction that 30% NaOH was added in diosmin and the reaction mixture was stirred for 1 h at 60 ℃.CONCLUSION The chemical reaction can remove 6-iododiosmin from diosmin efficiently and it can be used for the purification of diosmin.

关 键 词：橙皮苷 地奥司明 6-碘代地奥司明 正交试验 

分 类 号：R914[医药卫生—药物化学]