Is cerebral cavernous malformation a pre-glioma lesion？  

作　　者：ZHANG Ji-yang MING Zong-yi WU An-hua 

机构地区：[1]Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China [2]Department of Neurosurgery, 463 Hospital, Shenyang, Liaoning 110042, China

出　　处：《Chinese Medical Journal》2012年第24期4511-4513,共3页中华医学杂志（英文版）

基　　金：This work was supported by grants from National Natural Science Foundation of China （No. 81172409）, and National ＂863＂ Key Project （No. 2012AA02A508）.

摘　　要：Glioma is the most malignant tumor in the brain, the origin of glioma is still unknown. Recently some papers indicated that glioma may be developed from cerebral cavernous malformation （CCM）. We describe a man with a right temporal lobe CCM, after gamma-knife radiotherapy, the patient developed a low-grade astrocytoma in the area of the preexistent CCM. This case, together with other reports, may indicated an oncogenetic properties of CCM, and we proposed that CCM may be a pre-glioma lesion.Glioma is the most malignant tumor in the brain, the origin of glioma is still unknown. Recently some papers indicated that glioma may be developed from cerebral cavernous malformation （CCM）. We describe a man with a right temporal lobe CCM, after gamma-knife radiotherapy, the patient developed a low-grade astrocytoma in the area of the preexistent CCM. This case, together with other reports, may indicated an oncogenetic properties of CCM, and we proposed that CCM may be a pre-glioma lesion.

关 键 词：GLIOMA cerebral cavernous malformation RADIOTHERAPY 

分 类 号：R739.4[医药卫生—肿瘤]