4-羟基-α-氰基肉桂酸衍生物的设计合成及在质谱法手性识别氨基酸中的应用(英文)  

Design,synthesis of 4-hydroxyl-α-cyanocinnmaic acid derived compounds and their applications in chiral recognition of amino acids by mass spectrometry

作　　者：罗小雨[1] 王海星[2] 张舒[2] 陈鹏[1] 郑欢欢[1] 陈河如[1,3] 姚钟平[2] 

机构地区：[1]暨南大学药学院中药及天然药物研究所,广东广州510632 [2]手性科学国家重点实验室,香港科技大学应用生物与化学系 [3]广东省中药药效物质基础及创新药物研究重点实验室,广东广州310632

出　　处：《暨南大学学报（自然科学与医学版）》2013年第1期106-114,共9页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：National Natural Scientific Foundation of China(81172982);Science and Technology Project of Guangdong Province(2010A030100006)

摘　　要：设计合成了4对以脯氨酸和4-羟基-α-氰基肉桂酸(CHCA)为骨架、作为手性选择子的化合物。通过ESI-MS/MS质谱方法研究氨基酸与手性识别子所形成的质子化二聚体和三聚体,评估了这些化合物对19种氨基酸的手性识别作用。探讨了手性识别子结构变化对氨基酸手性识别作用的影响。Four pairs of compounds designed based on scaffolds of proline and 4-hydroxy-α-cyanocynnmaic acid （CHCA） have been synthesized as the chiral selectors. Chiral recognition of these compounds towards 19 common amino acids was evaluated by investigating the ESI-MS/MS spectra of the protonated dimers and trimers formed between the amino acids and the chiral selectors. Effects of the structural change of the chiral selectors on chiral recognition towards the amino acids were discussed in this study.

关 键 词：手性识别 质谱 氨基酸 脯氨酸 4-羟基-α-氰基肉桂酸 

分 类 号：R914.5[医药卫生—药物化学]