Neuroprotective role of fibronectin in neuron-glial extrasynaptic transmission  

作　　者：Jintang Wang Ling Yin Zheng Chen 

机构地区：[1]Institute for Geriatric Clinic and Rehabilitation,Beijing Geriatric Hospital [2]Institute of Medical Informatics,General Hospital of PLA

出　　处：《Neural Regeneration Research》2013年第4期376-382,共7页中国神经再生研究（英文版）

基　　金：supported by a grant from the National Science and Technology Infrastructure Platform,Ministry of Science and Technology,No. 2005DKA32400

摘　　要：Most hypotheses concerning the mechanisms underlying Parkinson＇s disease are based on altered synaptic transmission of the nigrostriatal system. However, extrasynaptic transmission was recently found to affect dopamine neurotransmitter delivery by anisotropic diffusion in the extracellular matrix which is modulated by various extracellular matrix components such as flbronectin. The present study reviewed the neuroprotective effect of fibronectin in extrasynaptic transmission. Fibronectin can regulate neuroactive substance diffusion and receptor activation, and exert anti- neuroinflammatory, adhesive and neuroprotective roles. Fibronectin can bind to integrin and growth factor receptors to transactivate intracellular signaling events such as the phosphatidylinositol 3-kinase/protein kinase B pathway to regulate or amplify growth factor-like neuroprotective actions. Fibronectin is assembled into a fibrillar network around cells to facilitate cell migration, molecule and ion diffusion, and even drug delivery and treatment. In addition, the present study analyzed the neuroprotective mechanism of fibronectin in the pathogenesis of Parkinson＇s disease, involving integrin and growth factor receptor interactions, and discussed the possible therapeutic and diagnostic significance of fibronectin in Parkinson＇s disease.Most hypotheses concerning the mechanisms underlying Parkinson＇s disease are based on altered synaptic transmission of the nigrostriatal system. However, extrasynaptic transmission was recently found to affect dopamine neurotransmitter delivery by anisotropic diffusion in the extracellular matrix which is modulated by various extracellular matrix components such as flbronectin. The present study reviewed the neuroprotective effect of fibronectin in extrasynaptic transmission. Fibronectin can regulate neuroactive substance diffusion and receptor activation, and exert anti- neuroinflammatory, adhesive and neuroprotective roles. Fibronectin can bind to integrin and growth factor receptors to transactivate intracellular signaling events such as the phosphatidylinositol 3-kinase/protein kinase B pathway to regulate or amplify growth factor-like neuroprotective actions. Fibronectin is assembled into a fibrillar network around cells to facilitate cell migration, molecule and ion diffusion, and even drug delivery and treatment. In addition, the present study analyzed the neuroprotective mechanism of fibronectin in the pathogenesis of Parkinson＇s disease, involving integrin and growth factor receptor interactions, and discussed the possible therapeutic and diagnostic significance of fibronectin in Parkinson＇s disease.

关 键 词：neural regeneration neurodegenerative diseases Parkinson＇s disease FIBRONECTIN integrin extrasynaptic transmission NEUROGLIA neuroprotection grants-supported paper photographs-containing paper neuroregeneration 

分 类 号：R742.5[医药卫生—神经病学与精神病学]