Combination of Aβ clearance and neurotrophic factors as a potential treatment for Alzheimer's disease  

作　　者：Lian-Feng Lin Min-Jing Liao Xiao-Yan Xue Wei Zhang Li Yan Liang Cai Xiao-Wen Zhou Xing Zhou Huan-Min Luo 

机构地区：[1]Department of Pharmacology,School of Medicine, Jinan University [2]Department of Laboratory Medicine, Medical College of Hunan Normal University [3]Ganzhou People's Hospital [4]Department of Pharmacology ,School of Medicine, Jinan University [5]Institute of Brain Sciences, School of Medicine, Jinan University [6]The Joint Laboratory of Brain Function and Health, Jinan University and The University of Hong Kong, Jinan University

出　　处：《Neuroscience Bulletin》2013年第1期111-120,共10页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(30672450);the National Basic Research Development Program(973Program)of China(2011CB707500)

摘　　要：There is no effective drug to treat Alzheimer＇s disease （AD）, a neurodegenerative disease affecting an estimated 30 million people around the world. Strongly supported by preclinical and clinical studies, amyloid-beta （Aβ） may be a target for developing drugs against AD. Meanwhile, the fact that localized neuronal death/loss and synaptic impairment occur in AD should also be considered. Neuronal regeneration, which does not occur normally in the mammalian central nervous system, can be promoted by neurotrophic factors （NTFs）. Evidence from clinical trials has shown that both Aβ clearance and NTFs are potentially effective in treating AD, thus a new approach combining Aβ clearance and administration of NTFs may be an effective therapeutic strategy.There is no effective drug to treat Alzheimer＇s disease （AD）, a neurodegenerative disease affecting an estimated 30 million people around the world. Strongly supported by preclinical and clinical studies, amyloid-beta （Aβ） may be a target for developing drugs against AD. Meanwhile, the fact that localized neuronal death/loss and synaptic impairment occur in AD should also be considered. Neuronal regeneration, which does not occur normally in the mammalian central nervous system, can be promoted by neurotrophic factors （NTFs）. Evidence from clinical trials has shown that both Aβ clearance and NTFs are potentially effective in treating AD, thus a new approach combining Aβ clearance and administration of NTFs may be an effective therapeutic strategy.

关 键 词：Alzheimer’s disease AMYLOID-BETA neurotrophic factors TREATMENT 

分 类 号：R749.1[医药卫生—神经病学与精神病学]