饮用咖啡与子宫内膜癌发病风险相关性的系统评价  

Correlation between Coffee and Risk of Endometrial Cancer: A Meta-Analysis

作　　者：黄世金[1] 徐红[1] 韦玮[1] 

机构地区：[1]广西医科大学第一附属医院妇科,南宁530000

出　　处：《中国循证医学杂志》2013年第3期313-319,共7页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价饮用咖啡与子宫内膜癌发病风险的相关性。方法计算机检索CBM、CNKI、WanFang Data、PubMed、EMbase和e Cochrane Library(2012年第5期)数据库,收集国内外发表的关于子宫内膜癌发病风险与饮用咖啡相关性的前瞻性队列研究,检索时间截至2012年5月,并追溯所获文献的参考文献。由2位评价者按照纳入与排除标准独立筛选文献、提取资料并评价质量后,采用Stata 12.0软件进行统计分析。结果最终纳入10个队列研究,包括4 484例子宫内膜癌患者。Meta分析结果显示,与饮用咖啡量最少或不饮用咖啡的妇女相比,饮用咖啡量最多的妇女罹患子宫内膜癌的风险降低[RR=0.69,95%CI(0.62,0.78)],经常饮用咖啡的妇女罹患子宫内膜癌的风险降低[RR=0.83,95%CI(0.77,0.89)]。剂量–效应分析结果显示,妇女饮用咖啡每增加2杯/d,患子宫内膜癌的风险降低12%。结论妇女经常饮用咖啡(2杯/d以上)可降低子宫内膜癌的发病风险,大量饮用咖啡(5杯/d以上)可更明显降低子宫内膜癌发病风险。Objective To systematically evaluate the correlation between coffee and risk of endometrial cancer. Methods Such databases as CBM, CNKI, WanFang data, PubMed, EMbase and The Cochrane Library （Issue 5, 2012） were searched to collect the prospective cohort studies about correlation between coffee and endometrial cancer. The re trieval time was by the end of May 2012, and the references of the included literature were also retrieved. Two evaluators independently screened the literature according to the inclusion and exclusion criteria, extracted the data, and assessed the quality, and then the statistical analysis was conducted by using Stata 12.0 software. Results A total of 10 cohort studies involving 4 484 patients with endometrial cancer were included. The results of metaanalysis showed that, com pared with the women who didn＇t drink coffee or drank in the lowest dose, the women who drank coffee in the highest dose had a decreased risk of endometrial cancer （RR=0.69, 95%CI 0.62 to 0.78）, same as the women who drank coffee frequently （RR=0.83, 95%CI 0.77 to 0.89）. The results of doseresponse analysis revealed that, when there was an increase of 2 more cups of coffee per day, there was the risk of endometrial cancer decreased by 12%. Conclusion Drinking cof fee frequently （more than 2 cups per day） can decrease the risk of endometrial cancer which can be significantly decreased when drinking in a big dose （more than 5 cuds per day）.

关 键 词：子宫内膜癌 咖啡 咖啡因 系统评价 Meta分析 队列研究 

分 类 号：R737.33[医药卫生—肿瘤]