Role of calbindin-D28K in estrogen treatment for Parkinson’s disease  

作　　者：Chunhua Wang Chao Jiang Honghua Yuan Chenghua Xiao Dianshuai Gao 

机构地区：[1]Department of Neurobiology,Xuzhou Medical College [2]Department of Neurology,Xuzhou Medical College [3]Department of Neurology,Funing County People's Hospital

出　　处：《Neural Regeneration Research》2013年第8期702-707,共6页中国神经再生研究（英文版）

摘　　要：Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson＇s disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 1713 estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson＇s disease.Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson＇s disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 1713 estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson＇s disease.

关 键 词：neural regeneration neurodegenerative diseases ESTROGEN CALBINDIN-D28K Parkinson＇s disease dopaminergic neuron tyrosine hydroxylase photographs-containing paper NEUROREGENERATION 

分 类 号：R742.5[医药卫生—神经病学与精神病学]