取代水杨醛缩苯磺酰腙化合物的合成和清除羟自由基能力研究  

Synthesis of Substituted Salicylaldehyde Arylsulfonyl-hydrazone Compounds and Their Scavenging Capacity on Hydroxyl Free Radical

作　　者：李庆南[1,2] 叶婷君[2] 彭青[1] 蔡文峰[1] 张鲁勉[1] 何小英[1] 郑锦鸿[1] 

机构地区：[1]汕头大学医学院化学教研室 [2]汕头市中心医院药学科,广东汕头515041

出　　处：《汕头大学医学院学报》2013年第1期1-3,共3页Journal of Shantou University Medical College

摘　　要：目的:合成取代水杨醛缩苯磺酰腙化合物,并对其清除羟自由基(.OH)能力进行研究。方法:以苯磺酰肼和取代水杨醛为原料合成3种取代水杨醛缩苯磺酰腙;用邻二氮菲-Fe2+氧化法检测其对.OH的清除作用。结果:目标化合物能有效清除.OH,但活性弱于维生素C并有明显差异。结论:取代水杨醛缩苯磺酰腙类化合物具有一定的清除.OH的能力,水杨醛苯环上引入卤基有助于增强活性。Objective：To synthesize the substituted salicylaldehyde arylsulfonyl-hydrazone compounds,and to study their scavenging capacity for hydroxyl free radical（·OH）.Method：Three substituted salicylaldehyde arylsulfonyl-hydrazone compounds were systhesized from benzenesulfonylhydrazine and substituted salicylaldehyde,and depending on orthophenanthroline-Fe（Ⅱ）method,the scavenging capacity on ·OH was detected by spectrophotometry.Results：The target compounds could effectively scavenge ·OH,but the capacity was inferior to vitamine C.Conclusion：The synthesized substituted salicylaldehyde arylsulfonyl-hydrazone compounds can scavenge ·OH and the activity can be increased by introducing the halogen group to the benzene ring of salicylaldehyde.

关 键 词：取代水杨醛缩苯磺酰腙 邻二氮菲 羟自由基 

分 类 号：R914[医药卫生—药物化学] R965[医药卫生—药学]