Coordination of autophagy with other cellular activities  

作　　者：Yan WANG Zheng-hong QIN 

机构地区：[1]Department of Pharmacology and Laboratory of Aging and Nervous Diseases (SZS0703), Soochow University School of Pharmaceuti-cal Science, Suzhou 215123, China

出　　处：《Acta Pharmacologica Sinica》2013年第5期585-594,共10页中国药理学报（英文版）

基　　金：Acknowledgements This work was supported by grants from the National Natu- ral Science Foundation of China （No 81000547; 30930035）, the National Basic Research Program of China （No 2011CB510003）, and the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）.

摘　　要：The cell biological phenomenon of autophagy has attracted increasing attention in recent years, partly as a consequence of the dis- covery of key components of its cellular machinery. Autophagy plays a crucial rote in a myriad of cellular functions. Autophagy has its own regulatory mechanisms, but this process is not isolated. Autophagy is coordinated with other cellular activities to maintain cell homeostasis. Autophagy is critical for a range of human physiological processes. The multifunctional roles of autophagy are explained by its ability to interact with several key components of various cell pathways. In this review, we focus on the coordination between autophagy and other physiological processes, including the ubiquitin-proteasome system （UPS）, energy homeostasis, aging, pro- grammed cell death, the immune responses, microbial invasion and inflammation. The insights gained from investigating autophagic networks should increase our understanding of their roles in human diseases and their potential as targets for therapeutic interven- tion.The cell biological phenomenon of autophagy has attracted increasing attention in recent years, partly as a consequence of the dis- covery of key components of its cellular machinery. Autophagy plays a crucial rote in a myriad of cellular functions. Autophagy has its own regulatory mechanisms, but this process is not isolated. Autophagy is coordinated with other cellular activities to maintain cell homeostasis. Autophagy is critical for a range of human physiological processes. The multifunctional roles of autophagy are explained by its ability to interact with several key components of various cell pathways. In this review, we focus on the coordination between autophagy and other physiological processes, including the ubiquitin-proteasome system （UPS）, energy homeostasis, aging, pro- grammed cell death, the immune responses, microbial invasion and inflammation. The insights gained from investigating autophagic networks should increase our understanding of their roles in human diseases and their potential as targets for therapeutic interven- tion.

关 键 词：AUTOPHAGY APOPTOSIS UPS AGING IMMUNITY energy homeostasis cell growth 

分 类 号：Q959.116[生物学—动物学] TH742[机械工程—光学工程]