2007年北京市居民母乳中二噁英类化合物负荷水平调查  

The human body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans and dioxin-like polychlorinated biphenyls in residents＇ human breast milk from Beijing in 2007

作　　者：张磊[1,2] 刘印平[3] 李敬光[1] 赵云峰[1] 吴永宁[1] 

机构地区：[1]卫生部食品安全风险评估重点实验室(国家食品安全风险评估中心),北京100021 [2]中国疾病预防控制中心营养与食品安全所 [3]河北省疾病预防控制中心理化检验所

出　　处：《中华预防医学杂志》2013年第6期534-537,共4页Chinese Journal of Preventive Medicine

基　　金：十一五国家科技支撑计划（2007BAC27802）;国家高科技研究发展项目（2006AA06Z403）

摘　　要：目的调查北京地区居民母乳中多氯代苯并二噁英和多氯代苯并呋喃（PCDD／Fs）和二噫英样多氯联苯（dl—PCBs）的污染水平，评价一般人群PCDD／Fs和dl—PCBs的机体负荷状况。方法2007年在北京市11个区、县中采集母乳样品110份，制成11个混合样品后，采用同位素稀释技术以高分辨气相色谱-高分辨质谱（HRGC—HRMS）测定母乳样品中的PCDD／Fs和dl—PCBs。结果北京市母乳样品中二噁英类化合物含量最高的组分为八氯代二苯并二噁英（OCDD）和多氯联苯（PCB）-118、PCB．105，其含量中位数分别为20．6pg／g脂肪、4．07和1．63ng／g脂肪。按毒性当量（TEQ）计，北京市11个母乳混合样品中总二噁英类化合物含量中位数为7．4PgTEQ／g脂肪；最高的为通州区，含量中位数为13．5PgTEQ／g脂肪；最低的为平谷区，为4．3PgTEQ／g脂肪。结论目前北京市母乳中PCDD／Fs和dl-PCBs处于较低水平，但随着我国的快速工业化，人群此类物质的机体负荷水平有可能会上升，因此有必要持续跟踪监测。Objective To investigate contamination levels of polychlorinated dibenzo-p-dioxins and dibenzofurans （PCDD/Fs） and dioxin-like polychlorinated biphenyls （dl-PCBs） in human breast milk from Beijing residents, and evaluate the human body burden of PCDD/Fs and dl-PCBs of general population. Methods A total of 110 human milk samples were collected from 11 regions in Beijing in 2007. After 11 pooled samples were made, concentrations of PCDD/Fs and dl-PCBs in breast milk pooled samples were measured by a high resolution gas chromatography - high resolution mass spectrometry （ HRCG- HRMS） with isotope dilution. Results For congeners of PCDD/Fs and dl-PCBs in human breast milk from Beijing, the highest content of congeners was octachlorodibenzo-p-dioxin （OCDD）, polychlorinated biphenyl （PCB）-ll8, and PCB-105 with the median of 20.6 pg/g fat, 4.07 ng/g fat and 1.63 ng/g fat, respectively. The concentration median of total dioxins in 11 pooled human milk samples from Beijing was 7.4 pg TEQ/g fat. The highest was 13.5 pg TEQ/g fat from Tongzhou,and the lowest was 4. 3 pg TEQ/g fat from Pinggu. Conclusion The contamination level of PCDD/Fs and dl-PCBs in human milk from Beijing is relatively low. However, with the rapid industrialization in China, the human body burden of PCDD/Fs and dl-PCBs will be likely to rise. Thus,further studies should be conducted to continuously monitor the trend of contamination level.

关 键 词：乳 人 气相色谱-质谱法 生物学监测 二噁英类化合物 机体负荷 

分 类 号：R1[医药卫生—公共卫生与预防医学]