鼻咽癌染色体7q32区域微缺失的研究  

Detailed allelic loss mapping on 7q32 in nasopharyngeal carcinoma *

作　　者：唐湘娜[1] 阳剑波[1] 邓龙文[1] 江宁[1] 周鸣[1] 曾朝阳[1] 谢奕[1] 谭国林 邱元正 李桂源[1] 

机构地区：[1]湖南医科大学肿瘤研究所,长沙410078 [2]附属第三医院耳鼻喉科 [3]湘雅医院耳鼻喉科

出　　处：《中华医学遗传学杂志》2000年第3期153-156,共4页Chinese Journal of Medical Genetics

摘　　要：目的　进一步明确鼻咽癌染色体 7q32的 D7S5 0 0 - D7S495附近区域高频率等位基因缺失的范围。方法　采用更高密度的微卫星标记位点 ,分析 30个鼻咽癌病例等位基因杂合性缺失的情况。结果30例患者中有 19例 (6 3.3% )存在杂合性缺失 ;D7S5 0 0 - D7S5 0 9- D7S495是高频率缺失集中的区域 ,共同缺失区在 D7S5 0 9附近。结论　 D7S5 0Objective The present research group had found high frequency of loss of heterozygosity (LOH) of D7S500 D7S495 on chromosome band 7q32 in nasopharyngeal carcinoma, this study was conducted to further find the deletion region. Methods Higher density of loci on 7q32 in 30 tumors was studied by using microsatellite analysis. Results The frequency of LOH was 63.3%. The highest frequency of LOH was identified at the loci of D7S500 D7S509 D7S495, among which a common deletion of D7S509 was found.Conclusion A putative tumor suppressor gene may be present around D7S509.

关 键 词：鼻咽癌 染色体7q32 等位基因缺失 抑癌基因 

分 类 号：R739.63[医药卫生—肿瘤]