沉香茶提取物的体外抗氧化和体内降血脂作用评价  

Evaluation of the in vitro Antioxidant Activity and in vivo Blood Lipid-lowering Capability of Chenxiang Tea Extracts

作　　者：陈地灵[1] 吴祎[2] 林励[2] 帅欧[2] 汪科元 张鹤鸣[1] 刘颂豪[1] 

机构地区：[1]华南师范大学药物研究院,广东广州510631 [2]广州中医药大学中药学院,广东广州510006 [3]广东君元药业有限公司,广东广州510623

出　　处：《现代食品科技》2013年第6期1198-1201,1242,共5页Modern Food Science and Technology

基　　金：国家发改委高新技术产业化项目(国发办2011-56);惠州市科技计划项目(2010BO20010005)

摘　　要：本文以广东大面积种植的白木香叶为原料制成的沉香茶为研究对象,采用体外抗氧化法测定其水浸液的抗氧化能力,体内高血脂小鼠模型评价其降血脂作用。实验结果显示沉香茶水浸液具有较强的体外抗氧化能力和体内降血脂能力。其水浸液具有清除羟自由基(OH)、超氧阴离子(O2-)、DPPH自由基(DPPH)以及络合亚铁离子(Fe2+)和还原磷钼酸的能力,IC50分别为700.45±38.04、58.03±4.4、16.24±2.4、70.69±2.8、215.46±14.27 mg/mL;能明显降低高血脂症小鼠血清中TC、TG水平和升高HDL-C水平,与模型组比较,差异具有显著性(P<0.05)。This experiment studied the chengxiang tea extracts from the raw materials of leaves of Aquilaria sinensis（Lour.） Gilg.Its radical scavenging activity,reducing power and metal chelating activity were determined to assays the in vitro antioxidant activity,and hyperlipidemia model mice were used to evaluate the blood lipid-reducing capacity of the water-extracts from Chenxiang tea.The results showed that the water extracts from Chenxiang tea have strong free radical scavenging activity,effective reducing power and chelating ability,with their IC50 values being of 700.45±38.04,58.03±4.4,16.24±2.4,70.69±2.8 and 215.46±14.27 mg/mL,respectively.The tea extracts can reduce the levels of TG and TC and increase the level of HDL-C in hyperlipidemia model mice serum.Compared with the model group,the differences were significant（P0.05）.

关 键 词：沉香茶 自由基 抗氧化活性 降血脂 保健功能 

分 类 号：R285[医药卫生—中药学]