山楂膳食纤维改善功能性便秘及预防铅中毒作用  

Maythorn Dietary Fiber Ameliorates Functional Constipation and Prevents Lead Poisoning

作　　者：陈洪雨[1] 马蕾[1] 杨建乔[1] 赵文[1] 崔同[1] 

机构地区：[1]河北农业大学食品科技学院,河北省农产品加工工程技术中心,河北保定071001

出　　处：《食品科学》2013年第15期232-235,共4页Food Science

基　　金：国家自然科学基金项目(31071494);河北省自然科学基金项目(C2011204093)

摘　　要：目的:研究山楂膳食纤维的改善功能性便秘及预防铅中毒功效。方法:1)将小鼠分为溶剂对照组、模型对照组和山楂膳食纤维低、中、高剂量组,灌胃10d后建立功能性便秘模型,观察山楂膳食纤维对小鼠小肠推进率、排便时间和排便质量的影响;2)通过制造预防性高铅动物模型,观察不同剂量的山楂膳食纤维及Na2CaEDTA阳性对照组对小鼠血液、肝脏及股骨中铅含量的影响。结果:山楂膳食纤维可提高小鼠的小肠推进率、缩短首粒排黑便时间和增加排便质量,且中、高剂量组具显著性差异(P<0.05);此外,低、中、高剂量组小鼠的的肝脏铅、全血铅、股骨铅含量均较模型组有所下降,其中中、高剂量组呈显著性差异(P<0.05)。结论:山楂膳食纤维在500mg/(kg.d)的剂量条件下对小鼠具有显著的润肠通便和驱铅功效,可有效改善功能性便秘,预防铅中毒。Objective： To explore the ameliorative effect of maythorn dietary fiber （MDF） on functional constipation and its preventive effect on lead poisoning. Methods： Mice were divided into 5 groups as follows： blank control, model control, and MDF low dose, middle dose and high dose groups. Functional constipation model was established after oral administration for 10 d. The intestinal motion rate, defecation time and feces weight of all the mice were investigated. A prophylactic lead-poisoning model was developed and employed to observe the effects of different doses of MDF and positive control on Pb content in the liver, blood and femur of mice. Results： The motional rate of ink in the intestine was enhanced by MDF administration, initial defecation time was abridged, and total feces weight increased when compared to the model control group. Moreover, in the MDF groups, Pb content in liver, blood, and femur declined when compared to the model control group, and the middle-dose and high-dose groups displayed a statistical significance. Conclusion： The administration of 500 mg/（kg d） of maythorn dietary fiber has effective defecation-promoting and lead-removing capacity in mice, which is beneficial for relieving functional constipation and preventing lead poisoning.

关 键 词：山楂膳食纤维 保健功能 便秘 排铅 

分 类 号：R151[医药卫生—营养与食品卫生学]