以2-甲基-2-取代苯氧基丙酸为离去基团的铂(Ⅱ)配合物的合成、表征及细胞毒活性(英文)  

Synthesis,characterization and cytotoxicity of platinum(Ⅱ) complexes with 2-methyl-2-substituted phenoxypropanoic acid as leaving ligands

作　　者：吴明明[1] 房雷[2] 苟少华[2] 陈莉[1] 

机构地区：[1]中国药科大学天然药物化学教研室,南京210009 [2]东南大学药物研究中心,南京211187

出　　处：《中国药科大学学报》2013年第4期303-306,共4页Journal of China Pharmaceutical University

摘　　要：设计合成了一系列以2-甲基-2-取代苯氧基丙酸为离去基团的二价铂配合物,其结构经红外光谱、核磁和质谱确证。采用MTT法对3种肿瘤细胞进行抗增殖活性研究,结果显示化合物对胃癌细胞(SGC-7901)活性较好,对肝癌细胞(HepG2)和非小细胞肺癌细胞(A549)活性较弱或无活性。A class of novel platinum（Ⅱ） complexes with 2-methyl-2-substituted phenoxypropanoic acids as leaving ligands were designed and synthesized.All complexes were characterized by IR,1H NMR and ESI-MS spectra.The in vitro antiproliferative activities were tested by MTT assay against three human cancer cell lines,indicating that the complexes showed selective cytotoxicity to human gastric cancer cell lines（SGC-7901） with only weak antiproliferative activities were observed against human hepatocellular carcinoma cell line（HepG2） and human non-small cell lung cancer cell line（A549）.

关 键 词：铂(Ⅱ)配合物 合成 2-甲基-2-取代苯氧丙酸 细胞毒性 

分 类 号：R914.5[医药卫生—药物化学]