青钱柳胶囊的装量稳定性及其降糖功效评价  

Content stability and hypoglycemic effect of Cyclocarya paliurus capsule

作　　者：李婷婷[1] 吴彩娥[1] 方升佐[1] 范龚健[1] 应瑞峰[1] 吴海霞[1] 

机构地区：[1]南京林业大学森林资源与环境学院,江苏南京210037

出　　处：《食品工业科技》2013年第19期337-340,共4页Science and Technology of Food Industry

基　　金：江苏高校优势学科建设工程资助项目(PAPD);国家林业局林业公益性行业科研专项项目(200904046)

摘　　要：对影响青钱柳硬胶囊装量稳定性的相关指标进行了考察,并通过动物实验评价了该青钱柳硬胶囊的药效学作用。装量稳定性主要检测了青钱柳硬胶囊颗粒的含水量、堆密度和休止角等指标。药效学作用则通过链佐霉素(STZ)诱导建立了糖尿病小鼠模型,将其随机分成模型组、消渴丸阳性对照组、青钱柳胶囊高、中、低剂量组,同时以正常小鼠做对照组,连续给药3周后,测定各组小鼠的多项生理生化指标,并取胰腺进行病理组织检查。结果显示,该青钱柳硬胶囊颗粒的含水量、堆密度和休止角,均在较理想的范围内。青钱柳胶囊高剂量组不仅可以极显著的降低(与模型组相比p<0.01)糖尿病小鼠的血糖值和总胆固醇量,改善肝糖原含量和受试小鼠的体质量,而且可以增加胰岛数目,增大胰岛面积,减轻胰岛细胞变性程度。上述结果表明该青钱柳胶囊的装量稳定性较好,且对STZ所诱导的糖尿病小鼠的典型病症具有改善和治疗作用。The factors affected content stability and the hypoglycaemic activity of Cyclocarya pafiurus capsule were examined in this paper.The content stability of Cyclocarya paliurus capsule was evaluated by measuring the values of moisture content, bulk density and angle of repose.Diabetes was induced in mice by using streptozotocin （STZ） ,diabetic mice were randomly divided into model control, normal control,positive control and low, medium and high- dose Cyclocarya pafiurus capsule treatment groups.After feeding for 3 weeks, several physiological indexes were measured,and histopathological examination of mouse pancreas was observed.The results showed the values of moisture content, bulk density and angle of repose were all in the ideal range.Compared with model control, high- dose Cyclocarya pafiurus capsule not only significantly reduced （ p 〈 0.0! ） blood glucose and total cholesterol levels, improved body weight and hepatic glycogen levels in diabetic mice, but also increased the number and area of islet cell, promoted the recovery of islet cell necrosis.Cyclocarya paliurus capsule present better content stability and had therapeutic effects on diabetic mice induced by STZ.

关 键 词：青钱柳硬胶囊 装量稳定性 降糖作用 糖尿病小鼠模型 

分 类 号：TS201.4[轻工技术与工程—食品科学]