药物苦度的定量及其与浓度的关系研究  

Study on Quantitation of Bitterness Intensity and Relationship between Bitterness Intensity&Concentration of Bitter Drug

作　　者：李学林[1] 张杏芬[2] 刘瑞新[1] 李慧玲[2] 仇继玺[2] 吴子丹[2] 

机构地区：[1]河南中医学院第一附属医院,郑州450000 [2]河南中医学院药学院,郑州450008

出　　处：《世界科学技术-中医药现代化》2013年第4期667-671,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委青年基金项目(81001646):基于味觉指纹技术的中药汤剂苦味抑制剂掩味规律研究,负责人:刘瑞新

摘　　要：目的:探讨药物苦度定量方法,建立苦味药物水溶液的口尝苦度与其浓度的相互关系。方法:以盐酸小檗碱为模型药物,配制成不同浓度的水溶液,由20名经筛选、培训合格的志愿者口尝测试其等级苦度,通过对数据特征的分析,并试验对数模型和威布尔曲线模型,经非线性拟合,最终建立了适宜的浓度与苦度的关系曲线。结果:苦度与浓度之间呈现曲线正相关关系,符合威布尔曲线模型(R2=0.997 3,RMSE=0.097 6,RMSECV=0.145 3)。结论:本文建立的模型拟合度好,可为药物苦度的定量及预测提供参考。This paper was aimed to study the quantitation method of bitterness intensity of bitter drug,and to explore the mutual relations between the bitterness intensity and the concentration of bitter drugs solution.The mod el drug of berberine hydrochloride,which was made into a series of solutions of different concentrations,was ap plied.Twenty volunteers,who were screened,trained and qualified,tasted the different concentration of aqueous solution,with the purpose of detecting the rank bitterness intensity.After analyzing the features of the data and testing the logarithm model and Weibull curve model,as well as nonlinear fitting,we finally set up the appropri ate relationship curve between the concentration and the bitterness intensity.There is a good curve positive corre lation between the bitterness intensity and the concentration,which is consistent with the Weibull curve model（R2 = 0.9973,RMSE = 0.0976,RMSECV = 0.1453）.The fitting degree of the model established in this paper is high,which provides a reference for quantitation and forecast of the drug bitterness.

关 键 词：苦度 浓度 威布尔模型 苦味 口尝法 掩味 

分 类 号：R285.1[医药卫生—中药学]