食品中化学危害暴露组与毒理学测试新技术中国技术路线图  

China roadmap to explore food chemical exposome and new toxicology test (TT21C)

作　　者：吴永宁[1] 

机构地区：[1]卫生部食品安全风险评估重点实验室(国家食品安全风险评估中心),北京100021

出　　处：《科学通报》2013年第26期2651-2656,共6页Chinese Science Bulletin

基　　金：国家重点基础研究发展计划(2012CB720804);国家科技支撑计划(2012BAK01B01);卫生行业公益性科研专项(201202005)资助

摘　　要：对于中国食品安全评估结果用于风险管理的转化技术路线图进行简单评述.传统食品安全风险评估依赖于确定性模型技术,现有毒理学测试存在由动物外推到人的缺陷,现有膳食暴露没有实现个体化暴露组的评估.本文阐述了21世纪毒理学测试新技术(TT21C)和暴露科学的新动向,特别是中国食品安全风险评估中转化毒理学和暴露组学平台建设的中国技术路线图.This is a brief perspective on China roadmap for risk management technology translation dealing with the new outcome from risk assessment. Traditionally, risk assessment is based on deterministic endpoints. From this start point, the disadvantage is reviewed in current toxicology test and dietary exposure, e.g., the result extrapolation from high dose in animal test to human being, rare in individuals＇ exposomes. The vision and strategy has been explored for exposure science and toxicity testing in the 21st century （TT21C）, China roadmap should been explored how to establish the platform and combining translational toxicology and exposomics in food safety risk assessment in China.

关 键 词：化学危害 暴露组 TT21C 中国技术路线图 食品安全 

分 类 号：R155.5[医药卫生—营养与食品卫生学]