广东汉族人群罕见等位基因FGA-13的研究  

Identification of a rare allele FGA-13 in Guangdong Han population

作　　者：章雅清[1] 陈维红[2] 陆惠玲[2] 

机构地区：[1]海南省血液中心输血研究室,570311 [2]中山大学中山医学院法医物证教研室

出　　处：《中华医学遗传学杂志》2013年第6期742-744,共3页Chinese Journal of Medical Genetics

摘　　要：目的确认广东汉族人群罕见的FGA-13等位基因。方法应用PCR-短串联重复和DNA序列分析技术，对母子亲子鉴定中的罕见等位基因FGA-OL进行检测。结果序列分析结果显示FGA—OL等位基因的核心序列为[TTTC]。[TTTT][TTcT][cTTT]s[cTcc][TTcc]z，是罕见等位基因FGA-13。结论罕见等位基因FGA-13在广东汉族人群中也有分布，这对个体识别和亲权鉴定有重要意义。Objective To report on a rare allele FGA-13 identified in Guangdong Han population. Methods The rare allele was detected by PCR-STR and DNA sequencing. Results The core repeat sequence of rare allele FGA-OL is [TTTC] ETTTT3 [TTCT] [CTTT][ECTCC-] [TTCC]z, which has been determined as FGA-13. Conclusion The rare allele FGA-13 is also present in Guangdong Han population. This is significant for personal identification and paternity testing.

关 键 词：等位基因 广东汉族人群 序列分析 

分 类 号：R394[医药卫生—医学遗传学]