高含量DHA/EPA甘油三酯型鱼油对大鼠脂质代谢的影响  

Effects of high levels of DHA/EPA fish oil triglyceride type on the lipid metabolism in fatty liver rats

作　　者：毛磊[1] 朱昱哲[1] 张维刚[1] 王静凤[1] 

机构地区：[1]中国海洋大学食品科学与工程学院,山东青岛266003

出　　处：《食品工业科技》2013年第24期347-350,共4页Science and Technology of Food Industry

基　　金：海洋公益性行业科研专项(201105029);中国海洋大学本科生研究发展计划(OUC-SRDP);长江学者和创新团队发展计划(IRT1188)

摘　　要：研究高含量DHA/EPA甘油三酯型鱼油对大鼠脂质代谢的影响。将Wistar大鼠随机分为8组:正常对照组、模型对照组、阳性对照组、乙酯型鱼油对照组、低含量DHA/EPA甘油三酯型鱼油对照组和高含量DHA/EPA甘油三酯型鱼油低、中、高剂量组。采用在饲料中添加1%乳清酸的方法诱导建立脂肪肝大鼠模型,20d后检测大鼠血清总固醇(Total cholesterol,TC)和甘油三酯(Triglyceride,TG)含量、肝脏TC、TG含量和脂肪酸组成、粪便总脂质和TC含量。结果显示高含量DHA/EPA甘油三酯型鱼油能降低模型大鼠血清TC和TG含量;显著降低肝脏TC(p<0.01)、TG(p<0.01)含量,改善肝脏脂肪酸组成;显著提高粪便中总脂质(p<0.01)和TC(p<0.01)含量。提示高含量DHA/EPA甘油三酯型鱼油能有效调节非酒精性脂肪肝症大鼠的脂质代谢。To investigate the effect of high levels of DHA/EPA fish oil triglyceride type on the lipid metabolism in fatty liver rats. Fatty Liver Wistar rats were randomly divided into normal control group,model control group, positive control group,ethyl ester control group （EE control group）,low levels of DHA/EPA triglyceride control group （TG control group）, high levels of DHA/EPA triglyceride （DHA/EPA-TG） groups in low, medium and high dosage. The fatty liver model rat was induced by feeding a diet containing 1% orotic acid. After 20d treatment, the indexes followed were examined,such as the contents of TC and TG of serum the contents of TC,TG and fatty acid of liver,contents of total lipid and TC of fecal. Results showed that high levels of DHA/EPA fish oil triglyceride type observably decreased the contents of serum TC and TG,significantly caused a reduction of TC （p〈0.01）,TG （p〈0.01） levels and an improvement of fatty acid forms in liver and remarkably increased total lipid（p〈0.01） and TC（p〈0.01） levels in fecal. The above result suggested that the high level of DHA/EPA fish oil triglyceride type could improve the disturbance of lipid metabolism on fatty liver rats.

关 键 词：DHA EPA 甘油三酯 乳清酸 脂质代谢 非酒精性脂肪肝 

分 类 号：TS201.4[轻工技术与工程—食品科学]