基于遗传算法的安丝菌素P-3分批发酵动力学研究  

Genetic algorithm for batch fermentation kinetics of ansamitocion P-3

作　　者：朱晓媛[1] 黎继烈[1] 韦晓菊[1] 王卫[1] 

机构地区：[1]中南林业科技大学经济森林培育与保护教育部重点实验室,湖南长沙410004

出　　处：《中国酿造》2013年第12期101-104,共4页China Brewing

基　　金：中南林业科技大学研究生科技创新基金(CX2012B20)

摘　　要：安丝菌素是微生物来源的美登类生物碱,具有显著抗肿瘤活性。研究安丝菌素P-3(AP-3)产生菌珍贵橙色束丝放线菌ATCC31565分批发酵动力学。首先探讨了5L自控发酵罐中ATCC31565分批发酵过程中菌体生长、AP-3合成和基质消耗的变化规律。基于遗传算法对实验数据进行处理得到了ATCC31565分批发酵合成AP-3的动力学模型参数及遗传算法进化结果图。结果表明,基于遗传算法对动力学模型拟合较好,可以较好地描述ATCC31565生产AP-3的发酵动力学规律。Ansamitocion is a kind of maytansinoids from microorganism sources with potent antitumor activity.The fermentation kinetics for ansamitoein P-3（AP-3） producing Actinosynnema Pretiosum ATCC 31565 was studied.The microorganism growth,AP-3 formation and substrate consumption of ATCC 31565 throughout the fermentation in a 5 L stirred bioreactor were investigated.The kinetics model parameters and genetic algorithm （GA） evolution results of AP-3 which synthesized by ATCC 31565 batch fermentation were obtained by GA.The result showed that the kinetic models were fit well based on GA,which can provide a reasonable description for the fermentation kinetic discipline of ATCC31565 producing AP-3.

关 键 词：安丝菌素 抗体药物偶联物 分批发酵 动力学模型 遗传算法(GA) 

分 类 号：TQ920.1[轻工技术与工程—发酵工程]