生物转化合成β-苯乙醇代谢途径及其调控的研究  

Study on metabolic pathways of β-phenyl ethanol bioconversion and regulation

作　　者：杜闪[1] 王雪花[1] 杨政茂[1] 刘笑生[1] 宋焕禄[1] 王凤寰[2] 王肇悦[3] 

机构地区：[1]北京工商大学分子感官科学实验室,北京100048 [2]北京工商大学食品学院,北京100048 [3]中国科学院微生物研究所,北京100101

出　　处：《食品与发酵工业》2014年第1期168-173,共6页Food and Fermentation Industries

基　　金：北京工商大学研究生科研学术创新基金项目资助

摘　　要：β-苯乙醇是种具有玫瑰风味的芳香醇,目前在食品、化妆品、烟草及医药等方面有广泛应用。随着社会经济的发展,生物转化法生产β-苯乙醇备受关注。文中综述了微生物生物转化合成β-苯乙醇的两个代谢途径,分别是苯丙酮酸途径和艾氏途径,其中艾氏途径是利用微生物合成β-苯乙醇的首选途径,L-苯丙氨酸经转氨酶、脱羧酶及脱氢酶的作用,终转化为β-苯乙醇。着重介绍了艾氏途径中编码这3种酶相关基因的调控。β-phenyl ethanol is an aromatic alcohol with a rose-like odour.Now it has been well used in food, cosmetics,tobacco,medicine and so on.With the development of social economy,much attention has been paid to the product of β-phenyl ethanol by microbial biotransformation.This paper reviews two microbial biotransformation β-phenyl ethanol metabolic pathways,the phenylpyruvic acid pathway and the Ehrlich pathway,respectively.Of all, the Ehrlich pathway is considered as the preferred way for microbial biosynthesis β-phenyl ethanol,in which L-phenylalanine is catalyzed by aminotransferase,decarboxylase and dehydrogenase in turn,and eventually translated into β-phenyl ethanol.This paper focuses on the genes coding these three kinds of enzymes in the Ehrlich pathway and the regulation of the related genes.

关 键 词：Β-苯乙醇 艾氏途径 转氨酶 脱羧酶 脱氢酶 

分 类 号：TS201.2[轻工技术与工程—食品科学]