Atorvastatin induces autophagy of mesenchymal stem cells underhypoxia and serum deprivation conditions by activating the mitogen-activated protein kinase/extracellular signal-regulatedkinase pathway  

出　　处：《Chinese Medical Journal》2014年第6期1046-1051,共6页中华医学杂志（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China （No. 81170129 and No. 81000091）, the China Health Medical Development Foundation （No. 2011-H25）, the Research Fund of Capital Medical Development （No. 2007-2018）, 863 Program of China （No. 2011AA020110）, and the Postgraduates＇ Innovative Research Foundation of Peking Union Medical College （2012-1002-31）.

摘　　要：Background The survival ratio of implanted mesenchymal stem cells （MSCs） in the infarcted myocardium is low.Autophagy is a complex self-eating process and can be utilized for cell survival. We have found that atorvastatin （ATV）can effectively activate autophagy to enhance MSCs survival during hypoxia and serum deprivation （H/SD）. The mitogen-activated protein kinase/extracellular signal-regulated kinase （MEK/ERK） pathway is a non-canonical autophagy pathway.We hypothesized that the MEK/ERK pathway mediated ATV-induced autophagy of MSCs under H/SD.

关 键 词：mesenchymal STROMAL cells myocardial infarction AUTOPHAGY hydroxymethylglutaryl-CoA REDUCTASE inhibitors signal TRANSDUCTION 

分 类 号：R[医药卫生]