裙带菜孢子多糖的体内抗氧化和免疫调节活性  

Antioxidant and immunomodulation activities of polysaccharide from sporophyll of Undaria pinnatifidain vivo

作　　者：奚倩[1,2] 赫丹 韩众鑫 余洋定[1,2] 孙黎明[1,2] 赵雅娉 张警予[1,2] 启航[1,2] 

机构地区：[1]大连工业大学食品学院,辽宁大连116034 [2]国家海洋食品工程技术研究中心,辽宁大连116034 [3]丹东市振安区种子管理站,辽宁丹东118000 [4]丹东市农产品质量检验监测中心,辽宁丹东118000

出　　处：《大连工业大学学报》2014年第2期79-83,共5页Journal of Dalian Polytechnic University

基　　金：国家高技术研究发展计划(863计划)项目(2014AA093602);国家海洋食品工程技术研究中心立项建设项目(2012FU125X03)

摘　　要：采用D-半乳糖建立氧化损伤小鼠模型,考察了裙带菜孢子叶多糖对模型小鼠体内抗氧化能力和免疫调节能力的影响。结果表明,裙带菜孢子叶多糖能够增强小鼠血清和脑中超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的活性,有效降低丙二醛(MDA)水平;显著提高了氧化损伤小鼠胸腺和脾脏的相对量、淋巴细胞增殖活性、NK细胞杀伤活性和抗体生成能力。裙带菜孢子叶多糖具有良好的体内抗氧化活性和免疫调节活性,具有潜在开发利用价值。An oxidative damage mice model was built up with D-galactose and PSU antioxidant and immunomodulation activities in vivo were determined. The MDA level was inhibited and the SOD and GSH-Px activities were enhanced by PSU in serum and brain of D galactose-treated mice. Spleen and thymus relative weight, lymphocyte proliferation, NK cell activity and antibody production were increased in the normal mice fed by PSU. PSU possess the potential value with good antioxidant and immunomodulation activities in vivo.

关 键 词：裙带菜中的孢子叶多糖 抗氧化活性 免疫调节活性 

分 类 号：TS254.9[轻工技术与工程—水产品加工及贮藏工程]