苦瓜提取物对BALB/c小鼠免疫功能的影响  

Effects of Momordica charantia extracton the immune function of BALB /c mice

作　　者：方瑾[1,2] 梁春来[1] 王伟 张文众[1] 孙拿拿[1] 贾旭东[1] 李宁 

机构地区：[1]国家食品安全风险评估中心卫生部食品安全风险评估重点实验室,北京100021 [2]中国疾病预防控制中心营养与食品安全所,北京100050

出　　处：《中国食品卫生杂志》2014年第3期223-226,共4页Chinese Journal of Food Hygiene

基　　金：食品化学污染物与新资源危害识别关键技术研究(2012BAK01B04)

摘　　要：目的探讨苦瓜提取物对小鼠免疫功能的影响。方法 200只雌性BALB/c小鼠,以体重分层随机分为4个大组,每大组50只,每大组再按体重随机分为5组,每组10只,分别为:阴性对照组(纯净水)、阳性对照组(环磷酰胺)、苦瓜水提物低、中、高剂量组(1.11、3.33、10.00 g/kg BW),连续灌胃30 d,观察苦瓜提取物对小鼠体液免疫、细胞免疫和非特异性免疫的影响。结果苦瓜提取物中、高剂量组IgA水平较阴性对照组升高(P<0.05),苦瓜提取物中剂量组IgG水平较对照组升高(P<0.05),苦瓜提取物低剂量组IL-6、IL-4水平较阴性对照组升高(P<0.05)。其他指标较对照组差异无统计学意义(P>0.05)。结论在本研究剂量下,苦瓜提取物对正常BALB/c小鼠免疫功能有一定的调节作用,尤其对体液免疫及细胞免疫可能有促进的作用,对非特异性免疫无明显影响。Objective To investigate the influence of Momordica charantia extract （MCE） on the immune function of BALB/c mice. MethodsA total of 200female BALB/c mice were randomly divided into negative control group （distilled water）, positive control group （cyclophosphamide） and three dosage group （1.11,3.33,0.00g/kg BW）, and the mice were administered intragastrically for 30days, the effects of MCE on humoral immunity, cellular immunity and nonspecific immunity of BALB/c mice were observed. ResultsThe IgA levels of the middle and high-dose group of MCE compared with the negative control group were significantly higher （P〈0.05）, the IgG levels of the low dose group were significantly higher than the control group （P〈0.05）, andthe IL-6, IL-4levels of the low dose group was significantly higher （P〈0.05） compared with the negative control group. Other indicators compared with the negative control group was not statistically significant （P〉0.05）.ConclusionUnder the dosage in this study, MCE had some regulatory effects on immune function of BALB/c mice, especially for humoral immunity and cellular immunity. However, there was no significant effects on non-specific immune.

关 键 词：苦瓜提取物 体液免疫 细胞免疫 非特异性免疫 

分 类 号：R285.5[医药卫生—中药学]