咖啡因-β-环糊精包结物的研究  

STUDY ON INCLUSION COMPLEX OF CAFFEINE AND β-CYCLODEXTRIN

作　　者：黄为钧[1] 周砚珠[1] 蒋曼[1] 李立璞[1] 金顺子[1] 谈夫[1] 

机构地区：[1]中国科学院化学研究所分子动态和稳态结构国家实验室

出　　处：《应用科学学报》1993年第1期51-57,共7页Journal of Applied Sciences

基　　金：北京中关村地区联合分析测试中心基金券资助

摘　　要：该文将咖啡因与β-环糊精形成包结物.研究了包结物的制备方法,并应用热重-差热分析、核磁共振谱和红外光谱三种方法鉴定了包结物的物性.实验结果表明,药物分子被包结在β-环糊精分子疏水性空穴内,其失重速率降低了,热稳定性提高了以及包结物中环糊精分子1位氢的δ值随咖啡因含量减少而增大.The inclusion complex of caffeine and β-cyclodextrin was prepared, and its properties were studied by using the thermogravimetry-differential thermal analysis, nuclear magnetic resonance and infrared spectroscopy. The experi mental results showed that the caffeine molecule was included in the hydrophobic cavity of β-cyclodextrin molecule and its thermal stability was increased.

关 键 词：咖啡因 环糊精 包结物 

分 类 号：R914[医药卫生—药物化学]