多巴胺D4受体基因与注意缺损多动障碍  

The Association Between Attention-deficit Hyperactivity Disorder and Dopamine Receptor D4 Gene

作　　者：张野[1] 忻仁娥[1] 江三多[1] 汤国梅[1] 钱伊萍[1] 李飞[1] 汪栋祥[1] 

机构地区：[1]上海市精神卫生中心,上海200030

出　　处：《遗传》2001年第5期413-414,共2页Hereditas（Beijing)

摘　　要：为探讨注意缺损多动障碍 (ADHD)与多巴胺D4受体基因 (dopamineD4receptorgene ,DRD4)间的关系 ,采用Amp -FLP的方法检测了上海地区汉族人群中 6 8例ADHD患者及其父母DRD4的多态性 ,数据采用基于单体型的单体型相对风险 (HHRR)及传递不平衡检验 (TDT)进行遗传关联分析。结果表明HHRR分析和复等位基因的TDT检验 ,均未显示出与ADHD的遗传关联性 (P >0 .0 5 )。提示上海地区人群中DRD4基因与ADHD无显著性关联。The present study was designed to investigate the association between attention-deficit hyperactivity disorder (ADHD) and the dopamine D4 receptor gene( DRD4 ).Amp-FLP was used to test the polymorphisms of DRD4 in 68 ADHD children and their parents from Shanghai.The haplotype-based haplotype relative risk( HHRR ) and transmission disequilibrium test ( TDT ) methods were used to analyze the association between DRD4 and ADHD.In our samples we found no significant association between DRD4 and ADHD ( P >0.05).Our results do not support that ADHD is associated with DRD4 in population in Shanghai.

关 键 词：注意缺损多动障碍 多巴胺D4受体基因 单体型相对风险 传递不平衡检验 

分 类 号：R749.94[医药卫生—神经病学与精神病学]