中国延边朝鲜族和汉族D17S30非翻译区的可变数目串联重复序列多态性研究  

A study on genetic polymorphism of VNTR of D17S30 locus in the Korean-Chinese and Han nationality of Yanbian

作　　者：全贵红[1] 陈华勇[1] 黄震英[2] 

机构地区：[1]延边大学医学院人体解剖学教研室,吉林延吉133000 [2]延边第二人民医院脑外科,吉林延吉133000

出　　处：《延边大学医学学报》2001年第3期157-160,共4页Journal of Medical Science Yanbian University

摘　　要：[目的 ]探讨中国延边朝鲜族和汉族D17S3 0位点的非翻译区的可变数目串联重复序列 .[方法 ]应用聚合酶链反应法 .[结果 ]中国延边朝鲜族和汉族等位基因频率总体分布之间均有显著性差异 ;D17S3 0位点的非翻译区的可变数目串联重复序列在中国延边朝鲜族和汉族中的观察杂合性、多态信息含量、个体鉴别力均高于 70 % ;中国延边朝鲜族和汉族中D17S3 0非翻译区的可变数目串联重复序列位点频率分别以A3和A1的为最高 .[结论 ]D17S3 0非翻译区的可变数目串联重复序列在中国延边朝鲜族和汉族中的基因频率分布具有很强的多态性 .OBJECTIVE? To study the variable number of tandem repeat(VNTR) of D17S30 locus in Korean-Chinese and Han nationality of Yanbian, China. ?METHODS?The polymerase chain reaction was used. ? RESULTS ? There had a significant difference in total distribution of allele frequencies of the D17S30 locus between the Korean-Chinese and Han nationality of Yanbian. The heterozygosity, polymorphism information content and individual identification of the D17S30 were all higher than 70%, and the frequency of variable number of tandem repeat of the D17S30 locus in the Korean-Chinese and Han nationality of Yanbian was the most higher in A3 and A1, respectively.?CONCLUSION?The distribution of allele frequencies of the D17S30 locus has the very strong polyorphism in Korean-Chinese and Han nationality of Yanbian, China.

关 键 词：等位基因 基因频率 聚合酶链反应 可变数目串联重复序列 中国 延边朝鲜族 汉族 

分 类 号：R394[医药卫生—医学遗传学] Q987[医药卫生—基础医学]