角膜真空冷冻干燥实验的传热传质分析  

Analysis of heat and mass transfer on cornea in vacuum freeze-drying experiment

作　　者：徐成海[1] 邹惠芬[1] 张世伟[1] 关奎之[1] 陈晓隆[2] 

机构地区：[1]东北大学机械工程与自动化学院,辽宁沈阳110004 [2]中国医科大学第二附属医院眼科,辽宁沈阳110004

出　　处：《真空》2001年第5期13-17,共5页Vacuum

基　　金：国家自然科学基金资助项目 (5 9876 0 0 8)

摘　　要：为保持角膜在真空冷冻干燥 (以下简称冻干 )过程中的活性 ,减少其内皮细胞的损伤 ,本文分析了冻干实验中前处理、预冻、干燥和复水检测等过程中 ,传热传质规律对角膜内皮细胞造成损伤的原因 ,在改进工艺参数的基础上 ,成功的冻干了合格的角膜。For keeping the corneal activity during the vacuum freeze-drying and reducing the damage of corneal endothelium cells, the law of heat and mass transfer is analyzed during cooling equilibrium stage, prefreezing stage, drying stage and reviving stage of the freeze-drying experiment. The damage reason of corneal endothelium cells is given, on the basis of technology parameter of four stages of the freeze-drying experiment, Freeze-drying cornea is successful.

关 键 词：角膜 冻干 传热 传质 真空冷冻干燥 内皮细胞 损伤 角膜移植 复水过程 

分 类 号：R779.65[医药卫生—眼科] R318.52[医药卫生—临床医学]