A paracrine role for white thermogenic adipocytes in innervation: an evidence-based hypothesis  

作　　者：Aejin Lee Ouliana Ziouzenkova 

机构地区：[1]Department of Human Sciences, The Ohio State University

出　　处：《Neural Regeneration Research》2019年第2期217-221,共5页中国神经再生研究（英文版）

基　　金：supported by NIH grants R21OD017244(to OZ);the National Center for Research Resources UL1RR025755(to OZ and AL);UL1TR001070(to OZ and AL);NCIP30CA16058(OSUCCC)(to OZ and AL);the NIH Roadmap for Medical Research(to OZ and AL);supported by the SEED Grant from College of Education and Human Ecology;Accelerator Grant from Office for Technology and Commercialization;Brain Injury program from the Ohio State University(to OZ and AL)

摘　　要：White adipose tissue(WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocular adipocytes express thermogenic genes and have phenotypic similarity with thermogenic brown adipose tissue. According to a current paradigm, multilocular adipocytes have a thermogenic function in WAT. In this mini review, we discuss data revealing heterogeneity among multilocular cell subsets in WAT and their functions beyond thermogenesis. We propose a hypothetical neuroendocrine role for multilocular adipocytes subsets in the formation of adaptive sensory-sympathetic circuits between the central nervous system and adipose tissue, which activate lipolysis and thermogenesis in WAT in high energy demand situations.White adipose tissue(WAT) stores energy and also plays an important endocrine role in producing adipokines for communication with the peripheral and central nervous system. WAT consists of the major lipogenic unilocular adipocytes and the minor populations of beige and brite multilocular adipocytes. These multilocular adipocytes express thermogenic genes and have phenotypic similarity with thermogenic brown adipose tissue. According to a current paradigm, multilocular adipocytes have a thermogenic function in WAT. In this mini review, we discuss data revealing heterogeneity among multilocular cell subsets in WAT and their functions beyond thermogenesis. We propose a hypothetical neuroendocrine role for multilocular adipocytes subsets in the formation of adaptive sensory-sympathetic circuits between the central nervous system and adipose tissue, which activate lipolysis and thermogenesis in WAT in high energy demand situations.

关 键 词：obesity THERMOGENESIS INNERVATION vitamin A ALDEHYDE dehydrogenase PARACRINE efferent AFFERENT brown adipose tissue 

分 类 号：R[医药卫生]