Evaluation of spectral domain optical coherence tomography parameters in discriminating preperimetric glaucoma from high myopia  

作　　者：Xiao-Yu Xu Hui Xiao Jing-Yi Luo Xing Liu 

机构地区：[1]State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University

出　　处：《International Journal of Ophthalmology(English edition)》2019年第1期58-65,共8页国际眼科杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China (No.81800879);Natural Science Foundation of Guangdong Province (No.2017A030310372);Fundamental Research Funds of the State Key Laboratory of Ophthalmology, China (No.2017QN05);Sun Yat-sen University Clinical Research 5010 Program (No.2014016)

摘　　要：AIM: To evaluate the diagnostic ability of macular ganglion cell-inner plexiform layer(GCIPL) thickness o b t a i n e d b y s p e c t r a l-d o m a i n o p t i c a l c o h e r e n c e tomography(SD-OCT) in discriminating non-highly myopic eyes with preperimetric glaucoma(PPG) from highly myopic healthy eyes. METHODS: A total of 254 eyes, including 76 normal controls(NC), 116 eyes with high myopia(HM) and 62 non-highly myopic eyes with PPG were enrolled. The diagnostic ability of OCT parameters was accessed by the areas under the receiver operating characteristic(AUROC) curve in two distinguishing groups: PPG eyes with nonglaucomatous eyes including NC and HM(Group 1), and PPG eyes with HM eyes(Group 2). Differences in diagnostic performance between GCIPL and RNFL parameters were evaluated. RESULTS: The minimum(AUROC curve of 0.782), inferotemporal(0.758) and inferior(0.705) GCIPL thickness were the top three GCIPL parameters in discriminating PPG from non-glaucomatous eyes, all of which had statistically significant lower diagnostic ability than average RNFL thickness(0.847). In discriminating PPG from HM, the best GCIPL parameter was minimum(0.689), statistically significant lower in diagnostic ability than average RNFL thickness(0.789) and three other RNFL thickness parameters of temporal and inferotemporal clock-hour sectors. CONCLUSION: The minimum GCIPL thickness is the best GCIPL parameter to detect non-highly myopic PPG from highly myopic eyes, whose diagnostic ability is inferiorto that of average RNFL thickness and RNFL thickness of several temporal and inferotemporal clock-hour sectors. The average RNFL thickness is recommended for discriminating PPG from highly myopic healthy eyes in current clinical practice in a Chinese population.AIM: To evaluate the diagnostic ability of macular ganglion cell-inner plexiform layer(GCIPL) thickness o b t a i n e d b y s p e c t r a l-d o m a i n o p t i c a l c o h e r e n c e tomography(SD-OCT) in discriminating non-highly myopic eyes with preperimetric glaucoma(PPG) from highly myopic healthy eyes.METHODS: A total of 254 eyes, including 76 normal controls(NC), 116 eyes with high myopia(HM) and 62 non-highly myopic eyes with PPG were enrolled. The diagnostic ability of OCT parameters was accessed by the areas under the receiver operating characteristic(AUROC) curve in two distinguishing groups: PPG eyes with nonglaucomatous eyes including NC and HM(Group 1), and PPG eyes with HM eyes(Group 2). Differences in diagnostic performance between GCIPL and RNFL parameters were evaluated.RESULTS: The minimum(AUROC curve of 0.782), inferotemporal(0.758) and inferior(0.705) GCIPL thickness were the top three GCIPL parameters in discriminating PPG from non-glaucomatous eyes, all of which had statistically significant lower diagnostic ability than average RNFL thickness(0.847). In discriminating PPG from HM, the best GCIPL parameter was minimum(0.689), statistically significant lower in diagnostic ability than average RNFL thickness(0.789) and three other RNFL thickness parameters of temporal and inferotemporal clock-hour sectors.CONCLUSION: The minimum GCIPL thickness is the best GCIPL parameter to detect non-highly myopic PPG from highly myopic eyes, whose diagnostic ability is inferiorto that of average RNFL thickness and RNFL thickness of several temporal and inferotemporal clock-hour sectors. The average RNFL thickness is recommended for discriminating PPG from highly myopic healthy eyes in current clinical practice in a Chinese population.

关 键 词：GANGLION cell-inner PLEXIFORM layer DIAGNOSTIC ability preperimetric GLAUCOMA high myopia. 

分 类 号：R[医药卫生]