Fluorescein angiography of retinal vascular involution after intravitreal injection of ranibizumab for retinopathy of prematurity  

作　　者：Yong Cheng Tie-Gang Liu Wei-Yi Li Ming-Wei Zhao Jian-Hong Liang 

机构地区：[1]Department of Ophthalmology,Peking University People's Hospital [2]Eye diseases and Optometry Institute [3]Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases [4]College of Optometry Peking,University Health Science Center [5]Clinical College of Ophthalmology,Tianjin Medical University [6]Tianjin Eye Hospital [7]Tianjin Key Laboratory of Ophthalmology and Visual Science [8]Tianjin Eye Institute [9]Department of Ophthalmology,Beijing Capital International Airport Hospital [10]Eye Hospital China Academy of Chinese Medical Sciences [11]College of Optometry,Peking University Health Science Center

出　　处：《International Journal of Ophthalmology(English edition)》2019年第1期79-82,共4页国际眼科杂志（英文版）

摘　　要：AIM: To describe the involution patterns of vessel growth of retina through fluorescein angiography(FA) of children, who had been under treatment up to 1 y previously intravitreal ranibizumab(IVR) as monotherapy for retinopathy of prematurity(ROP). METHODS: This is a retrospective study. The medical information and FA of 17 children(34 eyes) whose area of avascular retina from the ora serrata was more than two disc diameters(DD) were analyzed. RESULTS: Among 34 eyes, all were the presence of finger-shaped vessels and arteriolar-venular shunts(100%,34/34 eyes). Popcorn abnormalities were found in most of the eyes(94.1%, 32/34 eyes). Furthermore, in many cases(23.5%, 8/34 eyes), there were leakage persisting in the region of the junction between avascular and vascular retina. In contrast, just 2 eyes(5.9%) showed damage of retinal capillary bed and 3 eyes(8.8%) showed large area of retinal pigment epithelium(RPE) atrophy. CONCLUSION: Although IVR can be very effective in ROP, we should remain cautious as infants may remain avascular peripheral retinas and abnormal vessel. FA allows accurate visualization of vessel abnormalities in eyes with ROP, which will be helpful to affect assessment of disease activity and therapeutic effect.AIM: To describe the involution patterns of vessel growth of retina through fluorescein angiography(FA) of children, who had been under treatment up to 1 y previously intravitreal ranibizumab(IVR) as monotherapy for retinopathy of prematurity(ROP).METHODS: This is a retrospective study. The medical information and FA of 17 children(34 eyes) whose area of avascular retina from the ora serrata was more than two disc diameters(DD) were analyzed.RESULTS: Among 34 eyes, all were the presence of finger-shaped vessels and arteriolar-venular shunts(100%,34/34 eyes). Popcorn abnormalities were found in most of the eyes(94.1%, 32/34 eyes). Furthermore, in many cases(23.5%, 8/34 eyes), there were leakage persisting in the region of the junction between avascular and vascular retina. In contrast, just 2 eyes(5.9%) showed damage of retinal capillary bed and 3 eyes(8.8%) showed large area of retinal pigment epithelium(RPE) atrophy.CONCLUSION: Although IVR can be very effective in ROP, we should remain cautious as infants may remain avascular peripheral retinas and abnormal vessel. FA allows accurate visualization of vessel abnormalities in eyes with ROP, which will be helpful to affect assessment of disease activity and therapeutic effect.

关 键 词：RETINOPATHY of PREMATURITY FLUORESCEIN angiography ANTI-VEGF RANIBIZUMAB 

分 类 号：R[医药卫生]