The roles of activated protein C in experimental trauma models  

作　　者：Satoshi Gando Toshihiko Mayumi Tomohiko Ukai 

机构地区：[1]Acute and Critical Care Center.Department of Acute and Critical Care Medidne,Sapporo Higashi Tokushukai Hospital,Japan [2]Department of Emergency Medidne,School of Medicine,University of Occupational and Environmental Health,Japan [3]Department of Social Medicine,Graduate School of Medidne,Osaka University,Japan

出　　处：《Chinese Journal of Traumatology》2018年第6期311-315,共5页中华创伤杂志（英文版）

摘　　要：Trauma-induced coagulopathy is classified into primary and secondary coagulopathy, with the former elicited by trauma and traumatic shock itself and the latter being acquired coagulopathy induced by anemia, hypothermia, acidosis, and dilution. Primary coagulopathy consists of disseminated intravascular coagulation and acute coagulopathy of trauma shock (ACOTS). The pathophysiology of ACOTS is the suppression of thrombin generation and neutralization of plasminogen activator inhibitor-1 mediated by activated protein C that leads to hypocoagulation and hyperfibrinolysis in the circulation. This review tried to clarify the validity of activated protein C hypothesis that constitutes the main pathophysiology of the ACOTS in experimental trauma models.

关 键 词：Activated protein C COAGULOPATHY DISSEMINATED INTRAVASCULAR COAGULATION THROMBIN TRAUMA 

分 类 号：R[医药卫生]