Clinical characteristic and fecal microbiota responses to probiotic or antidepressant in patients with diarrhea-predominant irritable bowel syndrome with depression comorbidity: a pilot study  

作　　者：Lu Zhang Yi-Xuan Liu Zhe Wang Xiao-Qi Wang Jing-Jing Zhang Rong-Huan Jiang Xiang-Qun Wang Shi-Wei Zhu Kun Wang Zuo-Jing Liu Huai-Qiu Zhu Li-Ping Duan 

机构地区：[1]Department of Gastroenterology,Peking University Third Hospital,Beijing 100191,China [2]Department of Biomedical Engineering,College of Engineering,and Center for Quantitative Biology,Peking University,Beijing 100871,China [3]Department of Psychiatry,Institute of Mental Health,Peking University,Beijing 100191,China [4]Department of Psychological Medicine,Chinese People's Liberation Army (PLA)General Hospital,Beijing 100853,China

出　　处：《Chinese Medical Journal》2019年第3期346-351,共6页中华医学杂志（英文版）

基　　金：the grants from the National Twelfth Five-Year Plan for Science and Technology of China (No.2012BAI06B02);the National Natural Science Foundation of China (No.81670491);The Capital Health Research and Development of Special (No.2016-2- 4093).

摘　　要：To the Editor: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder that presents as abdominal pain with altered bowel habits. The pathophysiologic mechanism of IBS is not well understood, although many hypotheses have been proposed, including visceral hypersensitivity, gastrointestinal dysmotility, lowgrade inflammation of the intestinal mucosa, and dysfunction of the brain-gut interaction. Dysfunction of the braingut interaction is thought to be involved in IBS because a considerable proportion of patients with IBS have some form of psychologic comorbidity, such as depression or anxiety. In addition, mental and psychologic problems increase the risk for IBS and the symptom severity of IBS. Recently, changes in the gut microbiota have also been suggested to contribute to both IBS and depression. Our previous study demonstrated significant altered gut microbiota profiles in patients with diarrhea-predominant IBS (IBS-D) and depression.

关 键 词：FECAL microbiota RESPONSES DEPRESSION COMORBIDITY diarrhea-predominant IRRITABLE bowel syndrome 

分 类 号：R[医药卫生]