不同结构的蛋白编码基因的密码子偏性研究  

CODON USAGE IN GENES CODING FOR PROTEINSWITH DIFFERENT TERTIARY STRUCTURES

作　　者：顾万君[1] 马建民[1] 周童[1] 孙啸[1] 陆祖宏[1] 

机构地区：[1]东南大学吴健雄实验室,江苏南京210096

出　　处：《生物物理学报》2002年第1期81-86,共6页Acta Biophysica Sinica

基　　金：国家重大基础研究项目(G1998051200) ;国家自然科学基金资助项目(69525102)

摘　　要：利用聚类分析方法 ,对两类具有不同三级结构的75个蛋白的编码基因的密码子使用偏性进行了分析。75个基因样本序列按照对应蛋白的三级结构被很清晰的分成了两类 ,从而发现密码子的使用与蛋白质的三级结构有很大的相关性。Based on gene codon usage distance 75 genes coding for proteins with two different fingerprints were clustered, to analyze the relationship between gene codon usage and protein tertiary structure. It was found that 75 genes coding for proteins with different tertiary structure can be clearly classified into two groups according to the difference of codon usage bias, which suggests that codon usage is lighly corrclated to protein tertiary structure. The relationship between codon usage and protein tertiary structure is firstly found in the research of codon usage, which proves that gene sequence contains protein tertiary structure information.

关 键 词：蛋白编码基因 偏性 密码子 蛋白质三级结构 聚类分析 MRNA 

分 类 号：Q753[生物学—分子生物学]