“中式改良阿特金斯饮食”添加治疗对难治性癫痫患者的疗效研究  

Efficacy and side effects of Chinese style modified Atkins diet on patients with refractory epilepsy

作　　者：邓宇虹[1] 刘晓蓉[1] 黎冰梅[1] 廖卫平[1] 

机构地区：[1]广州医科大学附属第二院神经内科、广州医科大学神经科学研究所广东省重点实验室、神经遗传与离子通道病省部共建教育部重点实验室,广州510260

出　　处：《中华神经医学杂志》2014年第7期695-698,共4页Chinese Journal of Neuromedicine

基　　金：广东省医学科学技术研究基金（A2011259）

摘　　要：目的观察“中式改良阿特金斯饮食”治疗难治性癫痫的效果及副作用，为难治性癫痫的饮食治疗提供一种更易操作的新选择。方法收集广卅I医科大学附属第二医院神经内科自2010年1月至2013年5月收治的15例难治性癫痫患者进行前瞻性研究。所有患者均在药物治疗的基础上添加“中式改良阿特金斯饮食”疗法，即在约翰·霍普金斯医院制定的“改良阿特金斯饮食”基础上，增加了推荐限制热量和蛋白质，保证最低脂肪摄人，以份数来选择碳水化合物这3项措施。观察中式改良阿特金斯饮食的疗效、保留率及副作用。结果15例患者随访6月～3年。其中3例患者无发作，4例患者减少90％一99％的发作，6例患者减少50％~90％的发作，2例患者无效。6个月时的保留率为66％。5例患者1月后血脂升高。结论中式改良阿特金斯饮食具有与改良阿特金斯饮食相似的疗效、更高的保留率、更低的副作用，值得临床推广。Objective To observe the efficacy and side effect of Chinese style modified Atkins diet as add-on therapy in Chinese patients with intractable epilepsy to provide an easier operational choice for these patients. Methods A prospective study was performed on the clinical data of 15 patients with intractable epilepsy, admitted to our hospital from January 2010 to May 2013. On the basis of Johns Hopkins hospital operation method, other three measures were added： recommending calories and protein restriction, guaranteeing lowest fat intake, and choosing 1 g carbohydrate as one serving. All the patients were implemented with this method on the base of drugs. The efficacy, retention rate and side effect after this diet were observed. Results These patients were followed-up for 6 months to 3 years. Three patients （20%） had no attack, 4 （26%） had reduced onset of 〉90% attacks, 6 （40%） had reduced 50% -90% of their attacks, and the other two did not enjoy good effect. The retention rate at 6 months was 66%; 33% patients （5/15） had elevated blood lipids （including triglyceride and cholesterol）. Conclusion As compared with ketogenic diet, Chinese style modified Atkins diet achieves similar effect, enjoying higher retention rate and fewer side effect, which is worth for clinical promotion.

关 键 词：改良阿特金斯饮食 难治性癫痫 疗效 副作用 

分 类 号：R742.1[医药卫生—神经病学与精神病学]