云南3所特教学校聋生临床资料分析  

An Analysis of the Clinical Data of the Deaf Students at Three Special Education Schools in Yunnan Province

作　　者：孙勍[1] 蔺以楼 赵春丽[3] 单希征[1] 程静[4] 张秀菊[4] 张蕾[4] 王卉[4] 袁慧军[4] 

机构地区：[1]中国武警总医院耳鼻咽喉头颈外科,北京100045 [2]武警云南总队保山医院五官科,保山678000 [3]清华大学医院耳鼻咽喉科,北京100084 [4]中国人民解放军总医院耳鼻咽喉科研究所,北京100853

出　　处：《中国听力语言康复科学杂志》2014年第5期329-332,共4页Chinese Scientific Journal of Hearing and Speech Rehabilitation

基　　金：国家高技术研究发展计划（“863”高科技项目）《耳聋出生缺陷的发生机制及综合干预技术的研究》（2007AA022466）;科技部“十一五”支撑计划课题《儿童听障的分子致病机制研究》（2007BAI18800）

摘　　要：目的对云南3所特殊教育学校聋生人群进行系统性的耳聋临床资料分析，为开展耳聋基因的分子流行病学研究提供参考依据。方法了解聋生详细的耳聋病史；进行全身及耳鼻咽喉常规检查；进行纯音听阂测试及声导抗测试，了解聋生双耳听功能和中耳功能状况。结果聋生耳聋前有耳毒性药物用药史者占8．2％，有家族史者占19．5％，综合征性耳聋占5．3％，耳聋病因不明者亦占较大比例；汉族与非汉族聋生在综合征性耳聋和聋前用药史方面无显著差异，汉族聋生有家族史的比例高于非汉族聋生。结论云南省聋生可能的致聋原因有遗传性聋、药物性聋，但大部分聋生病因不明，尚需借助分子生物学理论和技术，从基因水平进行耳聋病因学的深入研究。。Objectivo To analyze the clinical data of the deaf students at three special education schools in Yunnan Province with the purpose of providing more information for the molecular epidemiological study of deafness-related genes. Methods The medical history of the deaf students was taken. All the subjects tznderwent general physical examination and otolaryngological examinations including pure-tone audiometry and acoustic immittance measurement. Results The epidemiological study found that 8.2% of the deaf students had a history of ototoxic drug use before deafness, 19.5% had a family history of deafness and 5.3% was diagnosed with syndromic hearing loss, but there were still a large proportion of students with deafness of unknown etiology. There was no significant difference in syndromic hearing loss and history of ototoxic drug use before deafness between Hart and non-Han students. However, the percentage of students with a family history of deafness among Han students was higher than that among non-Han students. Conclusion The possible etiologies for the deafness of deaf students in Yunnan province include genetic factors and ototoxic drug use, but the causes for most cases of deafness was unknown. Therefore, further genetic and molecular biological studies are still needed

关 键 词：耳聋 遗传学 聋生 

分 类 号：R179[医药卫生—妇幼卫生保健]