白骨壤果实中抗氧化活性成分研究  

Antioxidative Chemical Constituents from the Fruits of Avicennia marina

作　　者：易湘茜[1] 谢文佩[1,2] 颜栋美[2] 余炼[2] 范丽丽[1] 唐云丽[1] 

机构地区：[1]广西中医药大学药学院,广西南宁530001 [2]广西大学轻工与食品工程学院,广西南宁530004

出　　处：《广西科学院学报》2014年第4期253-256,共4页Journal of Guangxi Academy of Sciences

基　　金：广西近海海洋环境科学重点实验室开放基金项目(GXKLHY13-06);广西自然科学基金项目(2014GXNSFAA118048;2012GXNSFAA053160);广西科技兴海专项项目(GXZC2014G30578KLZBC);广西中医药大学中药学博士点建设工程开放课题(201410-02);2013年广西高校重点学科和重点实验室建设项目(桂教科研2013-8-2-16)资助

摘　　要：【目的】为获得高效的抗氧化先导化合物,对红树白骨壤（犃狏犻犮犲狀狀犻犪犿犪狉犻狀犪）果实中化学成分进行研究.【方法】采用柱色谱和高效液相色谱及细胞定量分析方法,对白骨壤果实中抗氧化活性成分进行研究,并运用色谱分析和文献对照方法,鉴定其化学结构.【结果】从白骨壤果实中分离鉴定了4个具有抗氧化活性的单体化合物,分别为tamarixetin-3-O-β-D-glucopyranoside（1）、3,4-dihydroxyphenethylalcohol-6-O-caffeoyl-β-D-glucoside（2）、类叶升麻苷（3）、焦地黄苯乙醇甙C（4）.化合物1～4的EC50值分别为（16.0±0.98）μM,（18.5±1.47）μM,（9.5±1.09）μM 和（12.0±0.89）μM.【结论】红树白骨壤果实中存在着具有强抗氧化活性成分（1～4）,且上述活性成份均为首次从该物种中分离获得.Objective]In order to obtain strong antioxidant compounds,the fruits of mangrove Avicennia marina were investigated.[Methods]The antioxidative constituents were isolated and analyzed by column chromatograph,HPLC and cell quantiative analysis.The structure of the constituents was identified by chromatograph analysis results and previous paper.[Re-sults]The fruits of mangrove Avicennia marina contains one flavonoid glycoside,tamarixetin-3-β-D-glucopyranoside (1),and three known phenylethyl glycosides,3,4-dihydroxyphen-ethylalcohol-6-O-caffeoyl-β-D-glucoside (2),acteoside (3)and jionoside C (4).The EC50 values of compounds 1~4 were (16.0±0.98)μM,(18.5±1.47)μM,(9.5±1.09)μM,and (12.0±0.89)μM,respectively.[Conclusion]The strong antioxidant compounds were obtained from the fruits of Avicennia marina,and these compounds were obtained from the fruits of this species for the first time.

关 键 词：红树 白骨壤 黄酮苷 苯乙基苷 抗氧化活性 

分 类 号：R914.4[医药卫生—药物化学]