Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy  

作　　者：PAN Zui MA JianJie 

机构地区：[1]Department of Internal Medicine,The Ohio State University Wexner Medical Center [2]Comprehensive Cancer Center,The Ohio State University Wexner Medical Center [3]Davis Heart and Lung Research Institute,The Ohio State University Wexner Medical Center [4]Department of Surgery,The Ohio State University Wexner Medical Center

出　　处：《Science China(Life Sciences)》2015年第1期48-53,共6页中国科学（生命科学英文版）

摘　　要：Store-operated Ca2+ entry(SOCE) controls intracellular Ca2+ homeostasis and regulates a wide range of cellular events including proliferation,migration and invasion.The discovery of STIM proteins as Ca2+ sensors and Orai proteins as Ca2+ channel pore forming units provided molecular tools to understand the physiological function of SOCE.Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells.This review focuses on recent advances in SOCE and its contribution to tumorigenesis.Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis,and targeting the SOCE pathway may provide a novel means for cancer treatment.Store-operated Ca^2＋ entry（SOCE） controls intracellular Ca^2＋ homeostasis and regulates a wide range of cellular events including proliferation,migration and invasion.The discovery of STIM proteins as Ca^2＋ sensors and Orai proteins as Ca^2＋ channel pore forming units provided molecular tools to understand the physiological function of SOCE.Many studies have revealed the pathophysiological roles of Orai and STIM in tumor cells.This review focuses on recent advances in SOCE and its contribution to tumorigenesis.Altered Orai and/or STIM functions may serve as biomarkers for cancer prognosis,and targeting the SOCE pathway may provide a novel means for cancer treatment.

关 键 词：Orai1 STIM1 Ca2＋ oscillations PROLIFERATION METASTASIS oncogenic 

分 类 号：R730.5[医药卫生—肿瘤]