液质法同时测定婴幼儿乳粉中7种有毒及禁用物质残留  

Simultaneous Determination of Seven Kinds of Toxic and Prohibited Substances Residues in Infant Milk Powder by LC-MS/MS

作　　者：于晓瑾[1] 王浩[1] 杨红梅[1] 郭启雷[1] 史海良[1] 

机构地区：[1]北京市海淀区产品质量监督检验所,国家食品质量安全监督检验中心,北京100094

出　　处：《食品研究与开发》2015年第4期133-137,共5页Food Research and Development

摘　　要：黄曲霉毒素M1、双酚A、醋酸甲孕酮、己烯雌酚、苯甲酸雌二醇、氯丙嗪和塞拉嗪是婴幼儿配方乳粉中可能存在的有毒及禁用物质。样品经过复溶后,采用含1%氨水的乙腈超声提取,使用MGⅢ-C18色谱柱,经梯度洗脱分离,用多反应监测正离子或负离子模式,可以一次性对婴幼儿配方乳粉中的7种有毒及禁用物质进行定性和定量测定。通过对100种市售婴幼儿配方奶粉进行分析,表明该方法可用于婴幼儿配方奶粉中黄曲霉毒素M1、双酚A、醋酸甲孕酮、己烯雌酚、苯甲酸雌二醇、氯丙嗪和塞拉嗪残留的同时测定。Aflatoxin M1, bisphenol A, medroxyprogesterone acetate, diethylstilbestrol, estradiol benzoate, chlorpromazine and xylazine are toxic and prohibited substances maybe present in infant milk powder. The samples were reconstituted, were ultrasonic extracted with alkaline acetonitrile, the HPLC separation was carried out on a MGⅢ-C18 column, with gradient elution. The detection of seven toxic and prohibited substances were carried out in the positive or negative multi-reaction monitoring （MRM） mode. The analysis results of one hundred commercially available infant milk powders can simultaneous determining the residues of aflatoxin M1, bispheno] A, medroxyprogesterone acetate, diethylstilbestrol, estradio] benzoate, chlorpromazine and xylazine in infant milk powder.

关 键 词：婴幼儿配方乳粉 黄曲霉毒素M1 双酚A 醋酸甲孕酮 己烯雌酚 苯甲酸雌二醇 氯丙嗪 塞拉嗪 

分 类 号：O657.63[理学—分析化学] TS252.51[理学—化学]