Substrates for clinical applicability of stem cells  

作　　者：Sanjar Enam Sha Jin 

机构地区：[1]Department of Biomedical Engineering,Thomas J Watson School of Engineering and Applied Sciences,State University of New York in Binghamton

出　　处：《World Journal of Stem Cells》2015年第2期243-252,共10页世界干细胞杂志（英文版）（电子版）

摘　　要：The capability of human pluripotent stem cells(h PSCs) to differentiate into a variety of cells in the human body holds great promise for regenerative medicine. Many substrates exist on which h PSCs can be self-renewed, maintained and expanded to further the goal of clinical application of stem cells. In this review, we highlight numerous extracellular matrix proteins, peptide and polymer based substrates, scaffolds and hydrogels that have been pioneered. We discuss their benefits and shortcomings and offer future directions as well as emphasize commercially available synthetic peptidesas a type of substrate that can bring the benefits of regenerative medicine to clinical settings.The capability of human pluripotent stem cells （hPSCs）to differentiate into a variety of cells in the human bodyholds great promise for regenerative medicine. Manysubstrates exist on which hPSCs can be self-renewed,maintained and expanded to further the goal of clinicalapplication of stem cells. In this review, we highlightnumerous extracellular matrix proteins, peptide andpolymer based substrates, scaffolds and hydrogelsthat have been pioneered. We discuss their benefitsand shortcomings and offer future directions as well asemphasize commercially available synthetic peptidesas a type of substrate that can bring the benefits ofregenerative medicine to clinical settings.

关 键 词：Human PLURIPOTENT stem cells EXTRACELLULARMATRIX protein Synthetic substrate PEPTIDE Polymer SCAFFOLD HYDROGEL 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]