Adiponectin: Probe of the molecular paradigm associating diabetes and obesity  

作　　者：Kakali Ghoshal Maitree Bhattacharyya 

机构地区：[1]Department of Biochemistry, University of Calcutta

出　　处：《World Journal of Diabetes》2015年第1期151-166,共16页世界糖尿病杂志（英文版）（电子版）

摘　　要：Type 2 diabetes is an emerging health challenge all over the world as a result of urbanization, high prevalence of obesity, sedentary lifestyle and other stress related factors compounded with the genetic prevalence. The health consequences and economic burden of the obesity and related diabetes mellitus epidemic are enormous. Different signaling molecules secreted by adipocytes have been implicated in the development of obesity and associated insulin resistance in type 2 diabetes. Human adiponectin, a 244-amino acid collagen-like protein is solely secreted by adipocytes andacts as a hormone with anti-inflammatory and insulinsensitizing properties. Adiponectin secretion, in contrast to secretion of other adipokines, is paradoxically decreased in obesity which may be attributable to inhibition of adiponectin gene transcription. There are several mechanisms through which adiponectin may decrease the risk of type 2 diabetes, including suppression of hepatic gluconeogenesis, stimulation of fatty acid oxidation in the liver, stimulation of fatty acid oxidation and glucose uptake in skeletal muscle, and stimulation of insulin secretion. To date, no systematic review has been conducted that evaluate the potential importance of adiponectin metabolism in insulin resistance. In this review attempt has been made to explore the relevance of adiponectin metabolism for the development of diabetes mellitus. This article also identifies this novel target for prospective therapeutic research aiming successful management of diabetes mellitus.Type 2 diabetes is an emerging health challenge all overthe world as a result of urbanization, high prevalenceof obesity, sedentary lifestyle and other stress relatedfactors compounded with the genetic prevalence. Thehealth consequences and economic burden of theobesity and related diabetes mellitus epidemic areenormous. Different signaling molecules secreted byadipocytes have been implicated in the developmentof obesity and associated insulin resistance in type2 diabetes. Human adiponectin, a 244-amino acidcollagen-like protein is solely secreted by adipocytes andacts as a hormone with anti-inflammatory and insulinsensitizingproperties. Adiponectin secretion, in contrastto secretion of other adipokines, is paradoxicallydecreased in obesity which may be attributable toinhibition of adiponectin gene transcription. Thereare several mechanisms through which adiponectinmay decrease the risk of type 2 diabetes, includingsuppression of hepatic gluconeogenesis, stimulation offatty acid oxidation in the liver, stimulation of fatty acidoxidation and glucose uptake in skeletal muscle, andstimulation of insulin secretion. To date, no systematicreview has been conducted that evaluate the potentialimportance of adiponectin metabolism in insulinresistance. In this review attempt has been made toexplore the relevance of adiponectin metabolism forthe development of diabetes mellitus. This article alsoidentifies this novel target for prospective therapeuticresearch aiming successful management of diabetesmellitus.

关 键 词：ADIPONECTIN OBESITY DYSLIPIDEMIA Type 2diabetes MELLITUS INSULIN resistance 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]