药物化学理论教学中的合理药物设计方法浅析  

Discussion of Rational Drug Design in Medicine Chemistry Teaching

作　　者：王远强[1] 张娅 蔡家利 林治华[1] 

机构地区：[1]重庆理工大学药学与生物工程学院,重庆400054

出　　处：《科技资讯》2015年第7期173-174,共2页Science & Technology Information

基　　金：重庆市高等教育学会高等教育科学研究项目(CQGJ13C442);重庆理工大学高等教育改革研究项目(2014YB12)

摘　　要：合理药物设计是现代药物化学重要组成部分,对指导创新药物研究具有指导作用,不仅可以有效提高药物研究效率、节省药物开发的研究成本,而且能够促进药学化学学科的快速发展。该文基于现代药物设计理论基础与技术方法,着重介绍基于性质、配体、受体、机理的药物设计方法及在药物化学教学中的相应案例,阐述药物化学中的合理药物设计思想。药物化学理论教学中融入创新药物设计理念,可增强学生在药物研究中的创新意识,为培养创新型药学人才奠定基础。Rational drug design is important component of medicine chemlstry,which can guide the innovative drug research. The rational drug design can not only improve the efficiency and save the cost of drug research,but also accelerate the development of medicine chemistry. Here,some important methods of drug design,such as properties based drug design,ligand based drug design, receptor base drug design are introduced in medicine chemistry,and the corresponding samples are used to demonstrate the idea of drug design. Obviously,the innovative drug design integrated into medicine chemistry teaching not only boosts the innovation consciousness in drug research,but also is the basis for cultivation of creative student.

关 键 词：药物化学 药物设计 教学研究 教学改革 

分 类 号：R914.2[医药卫生—药物化学]