Gastric mucosa in Mongolian and Japanese patients with gastric cancer and Helicobacter pylori infection  

作　　者：Takeshi Matsuhisa Yoshio Yamaoka Tomohisa Uchida Davaadorj Duger Battulga Adiyasuren Oyuntsetseg Khasag Tserentogtokh Tegshee Byambajav Tsogt-Ochir 

机构地区：[1]Department of Gastroenterology, Tama-Nagayama University Hospital, Nippon Medical School [2]Department of Environmental and Preventive Medicine, Oita University of Medicine [3]Department of Molecular Pathology, Oita University of Medicine [4]Vice President of Mongolian National University of Medical Sciences and President of Mongolian Society of Gastroenterology [5]Department of Endoscopy, Ulaanbaatar Songdo Hospital [6]Department of Gastroenterology, Mongolian National University of Medical Sciences [7]Department of Gastroenterology, Third Central State Hospital

出　　处：《World Journal of Gastroenterology》2015年第27期8408-8417,共10页世界胃肠病学杂志（英文版）

基　　金：Supported by(in part)National Institutes of Health,No.DK62813;Grants-in-Aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology(MEXT)of Japan,No.24406015,No.24659200,No.25293104,and No.26640114

摘　　要：AIM: To investigate the characteristics of gastric cancer and gastric mucosa in a Mongolian populationby comparison with a Japanese population.METHODS: A total of 484 Mongolian patients with gastric cancer were enrolled to study gastric cancer characteristics in Mongolians. In addition, a total of 208 Mongolian and 3205 Japanese consecutive outpatients who underwent endoscopy, had abdominal complaints, no history of gastric operation or Helicobacter pylori eradication treatment, and no use of gastric secretion inhibitors such as histamine H2-receptor antagonists or proton pump inhibitors were enrolled. This study was conducted with the approval of the ethics committees of all hospitals. The triple-site biopsy method was used for the histologic diagnosis of gastritis and H. pylori infection in all Mongolian and Japanese cases. The infection rate of H. pylori and the status of gastric mucosa in H. pylori-infected patients were compared between Mongolian and Japanese subjects. Age(± 5 years), sex, and endoscopic diagnosis were matched between the two countries.RESULTS: Approximately 70% of Mongolian patients with gastric cancer were 50-79 years of age, and approximately half of the cancers were located in the upper part of the stomach. Histologically, 65.7% of early cancers exhibited differentiated adenocarcinoma, where as 73.9 % of advanced can cersdisplayed undifferentiated adenocarcinoma. The infection rate of H. pylori was higher in Mongolian than Japanese patients(75.9% vs 4 8. 3 %, P<0.0001). When stratified by age, the prevalence was highest among young patients, and tended to decrease in patients aged 50 years or older. The anti-East-Asian Cag Aspecific antibody was negative in 99.4% of H. pyloripositive Mongolian patients. Chronic inflammation, neutrophil activity, glandular atrophy, and intestinal metaplasia scores were significantly lower in Mongolian compared to Japanese H. pylori-positive patients(P < 0.0001), with the exception of the intestinal metaplasia score of specimen from the greater curvature AIM: To investigate the characteristics of gastric cancer and gastric mucosa in a Mongolian populationby comparison with a Japanese population.METHODS: A total of 484 Mongolian patients with gastric cancer were enrolled to study gastric cancer characteristics in Mongolians. In addition, a total of 208 Mongolian and 3205 Japanese consecutive outpatients who underwent endoscopy, had abdominal complaints, no history of gastric operation or Helicobacter pylori eradication treatment, and no use of gastric secretion inhibitors such as histamine H2-receptor antagonists or proton pump inhibitors were enrolled. This study was conducted with the approval of the ethics committees of all hospitals. The triple-site biopsy method was used for the histologic diagnosis of gastritis and H. pylori infection in all Mongolian and Japanese cases. The infection rate of H. pylori and the status of gastric mucosa in H. pylori-infected patients were compared between Mongolian and Japanese subjects. Age(± 5 years), sex, and endoscopic diagnosis were matched between the two countries.RESULTS: Approximately 70% of Mongolian patients with gastric cancer were 50-79 years of age, and approximately half of the cancers were located in the upper part of the stomach. Histologically, 65.7% of early cancers exhibited differentiated adenocarcinoma, where as 73.9 % of advanced can cersdisplayed undifferentiated adenocarcinoma. The infection rate of H. pylori was higher in Mongolian than Japanese patients(75.9% vs 48.3 %, P<0.0001). W h e n stratified by age, the prevalence was highest among young patients, and tended to decrease in patients aged 50 years or older. The anti-East-Asian Cag Aspecific antibody was negative in 99.4% of H. pyloripositive Mongolian patients. Chronic inflammation, neutrophil activity, glandular atrophy, and intestinal metaplasia scores were significantly lower in Mongolian compared to Japanese H. pylori-positive patients(P < 0.0001), with the exception of the intestinal metaplasia score of specimen from the greater curvature

关 键 词：Chronic inflammation Gastric cancer Glandularatrophy HELICOBACTER PYLORI Intestinal METAPLASIA Japanese MONGOLIAN NEUTROPHIL activity Non-East-Asian-type strain 

分 类 号：R735.2[医药卫生—肿瘤]