过氧化物酶体增殖物激活受体γ辅激活因子1α与肌纤维类型转化及其表达调控研究进展  

Research Progress on the Relationship between Peroxisome Proliferators-activated Receptor-γ Coactivator-1α and Muscle Fiber-type Switching,and its Expression Regulation

作　　者：周招洪[1,2] 陈代文[1] 田刚[1] 肖竺宏 余冰[1] 

机构地区：[1]四川农业大学动物营养研究所,成都611130 [2]遵义市饲草饲料工作站,遵义563000

出　　处：《中国畜牧兽医》2015年第10期2636-2643,共8页China Animal Husbandry & Veterinary Medicine

基　　金：国家"973"计划(2012CB124701);四川省"生猪现代产业链关键技术研究集成与产业化示范"项目(2012NZ0001);贵州省草地生态畜牧业产业化科技扶贫项目(黔财农〔2014〕7号)

摘　　要：过氧化物酶体增殖物激活受体γ(PPAR-γ)辅激活因子1α(PGC-1α)是一种多功能的转录调节因子,广泛参与线粒体生物合成、能量代谢和糖脂代谢等过程。PGC-1α可通过多条信号通路调控畜禽骨骼肌肌纤维类型的转化,从而影响肉品质。因此,在转录和翻译水平上对PGC-1α的表达调控进行深入研究将为今后改善肉品质提供新的思路。日粮营养作为一种调控畜禽肉品质的重要方式,近年来,关于营养对PGC-1α活性的影响研究也逐渐开展起来,并取得了一些进展。作者概述了PGC-1α的结构、组织表达特点及PGC-1α调控肌纤维类型转化的机制,重点在转录和翻译水平介绍了PGC-1α的表达调控机制,并综述了日粮营养对PGC-1α活性的影响。Peroxisome proliferators-activated receptor-γ（PPAR-γ）coactivator-1α（PGC-1α）is a versatile transcriptional regulator.PGC-1αis characteristically involved in the regulation of several crucial cellular pathways including mitochondrial biogenesis,fatty acid oxidation,gluconeogenesis and so on.PGC-1αis significantly associated with meat quality,since it may affect the fibertype switching through several signaling pathways in livestock and poultry.Therefore,study on PGC-1αexpression regulation in the transcription and post-translation level can provide new strategies for improving the meat quality.In recent years,the effect of dietary nutrition on PGC-1αhas been also researched gradually for its importance in the regulation on meat quality in livestock and poultry.This review described the structure and expression patterns in tissues of PGC-1α,and its regulatory mechanism on muscle fiber-type switching,focusing on recent advances on its expression regulation in the transcription and post-translation level,also summarized the effect of dietary nutrition on PGC-1α.

关 键 词：PGC-1Α 肌纤维类型 转录水平 翻译水平 表达调控 营养 

分 类 号：S828[农业科学—畜牧学]